{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:17:27Z","timestamp":1780917447594,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Vancomycin (VCM) is essential for treating methicillin\u2010resistant\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    infections, but its use is limited by vancomycin\u2010induced nephrotoxicity (VIN). Although preclinical and small clinical studies suggest a protective role for vitamin E, real\u2010world evidence remains limited. We conducted a retrospective cohort study using a large\u2010scale Japanese electronic medical record database including adult patients who received intravenous VCM between 1996 and 2022. VIN was defined according to Kidney Disease Improving Global Outcomes criteria. The association between concomitant vitamin E use and VIN was evaluated using propensity score matching based on logistic regression and light gradient boosting machine models, followed by Kaplan\u2013Meier analysis and Cox proportional hazards regression. Robustness was examined using three analytical strategies, including adjustment for concomitant medications. Among 12\u2009411 eligible patients, 2267 (18.3%) developed VIN and 116 (0.9%) received vitamin E. After matching, vitamin E use was associated with a 10% lower incidence of VIN. Kaplan\u2013Meier analysis showed significantly lower cumulative incidence in the vitamin E group in two approaches. Across 63 Cox models, vitamin E consistently demonstrated a protective trend. These findings support the potential preventive role of vitamin E in maintaining VCM therapy.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.70245","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T03:34:56Z","timestamp":1779420896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective Effect of Vitamin E Against Vancomycin\u2010Induced Nephrotoxicity: A Large\u2010Scale Electronic Medical Record Study From Japan"],"prefix":"10.1111","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7343-5104","authenticated-orcid":false,"given":"Satoru","family":"Nakanishi","sequence":"first","affiliation":[{"name":"Division of Drug Informatics Keio University Faculty of Pharmacy  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shungo","family":"Imai","sequence":"additional","affiliation":[{"name":"Division of Drug Informatics Keio University Faculty of Pharmacy  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Saito","sequence":"additional","affiliation":[{"name":"Division of Drug Informatics Keio University Faculty of Pharmacy  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Kizaki","sequence":"additional","affiliation":[{"name":"Division of Drug Informatics Keio University Faculty of Pharmacy  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haru","family":"Iino","sequence":"additional","affiliation":[{"name":"Division of Drug Informatics Keio University Faculty of Pharmacy  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3846-0435","authenticated-orcid":false,"given":"Masami","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Division of Drug Informatics Keio University Faculty of Pharmacy  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4596-5418","authenticated-orcid":false,"given":"Satoko","family":"Hori","sequence":"additional","affiliation":[{"name":"Division of Drug Informatics Keio University Faculty of Pharmacy  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1488"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23042052"},{"key":"e_1_2_11_4_1","volume-title":"Clinical Practice Guideline for Drug\u2010Induced Kidney Injury 2016","author":"Japanese Society of Nephrology","year":"2016"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032\u2010025\u201002994\u2010w"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.87.164"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V12122585"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1461792"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742\u20107843.2007.00051.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735\u20105362.283813"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(07)61602\u2010X"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.70159"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.37737\/ace.24009"},{"key":"e_1_2_11_14_1","unstructured":"WHO Collaborating Centre for Drug Statistics Methodology \u201cATC\/DDD Index 2024 \u201d Oslo Norway retrieved January 16 2026 https:\/\/www.whocc.no\/."},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11454"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15429"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.632107"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00886\u201021"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006023"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2025.102701"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/bcp.70002"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106967"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874\u2010023\u201001936\u20102"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2024.8953"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.03.024"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/nure.12026"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1024\/0300\u20109831\/a000512"}],"container-title":["Basic &amp; 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