{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:09:03Z","timestamp":1789834143726,"version":"4.0.1"},"reference-count":166,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cognitive impairment represents the most prevalent complication of neurological diseases (NDs), which significantly affects the quality of life in affected patients. Current treatments primarily target neurotransmitter imbalances but do not act on the key pathological events such as Ca\n                    <jats:sup>2+<\/jats:sup>\n                    dyshomeostasis, oxidative stress, microglia activation, mitochondrial dysfunction and neuroinflammation that occur in the brain of patients with NDs. Therefore, existing treatments fail to stop the progressive cognitive decline in these diseases. Thus, there is a critical need for literature which covers the potential novel therapeutic targets along with their modulators for the effective treatment of cognitive impairment associated with NDs. Recently, transient receptor potential (TRP) channels have emerged as key regulators of these pathological events implicated in ND\u2010associated cognitive impairment. Many preclinical studies have demonstrated that pharmacological modulation of specific TRP channels can improve cognitive function in animal models of NDs. However, clinical translation of TRP channel modulators is still constrained due to a lack of subtype specificity, limited clinical data and difficulties in drug delivery across the blood\u2013brain barrier (BBB). In the present review, we have discussed the structural diversity of TRP channels, their role in regulating synaptic plasticity and cognitive function, and their potential as pharmacological targets for the treatment of cognitive impairment, which can provide a direction for future research in this field.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.70248","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T13:11:27Z","timestamp":1779973887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Transient Receptor Potential Channels in Modulating Synaptic Plasticity and Cognitive Function: Potential Role of Pharmacological Agents"],"prefix":"10.1111","volume":"139","author":[{"given":"Abhishek","family":"Sarkar","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research  Mohali Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnamoorthy","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Department of Applied Biology CSIR\u2014Indian Institute of Chemical Technology  Tarnaka Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7499-1658","authenticated-orcid":false,"given":"Ashok Kumar","family":"Datusalia","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular NeuroTherapeutics, Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research, Raebareli  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4221-4870","authenticated-orcid":false,"given":"Shyam Sunder","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research  Mohali Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_2_16_2_1","unstructured":"Dhaka and Bobrin \u201cCognitive Deficits \u2010 StatPearls \u2010 NCBI Bookshelf \u201d National Library of Medicine retrieved July 09 2025 https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559052\/."},{"key":"e_1_2_16_3_1","unstructured":"World Health Organization (WHO) \u201cWorld Failing to Address Dementia Challenge \u201d World Health Organization retrieved July 09 2025 https:\/\/www.who.int\/news\/item\/02\u201009\u20102021\u2010world\u2010failing\u2010to\u2010address\u2010dementia\u2010challenge."},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.1034243"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.617588"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12081628"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9101308"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.584513"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/112_2012_8"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104271"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201063577\u20105"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.611773"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.5483\/bmbrep.2017.50.5.038"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113527"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1123817"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2021.08.004"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386\u2010022\u201001370\u2010w"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3192"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2020.00008"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1240"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000445"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.171900"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010319\u201005161\u20101_10"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7289194"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2017.04.002"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/112_2022_74"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00782"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01675"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238\u2010010\u20100108\u20109"},{"key":"e_1_2_16_30_1","first-page":"5","volume-title":"Handbook of experimental pharmacology","author":"Nilius B.","year":"2014"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113915"},{"key":"e_1_2_16_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-6997(24)01403-0"},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003962"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001464\u2010x"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u2010981\u201010\u20107757\u20109_6"},{"key":"e_1_2_16_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u201094\u2010007\u20100265\u20103_37"},{"key":"e_1_2_16_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010023\u201000777\u2010y"},{"key":"e_1_2_16_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.046"},{"issue":"6","key":"e_1_2_16_39_1","first-page":"211","article-title":"TRPM7 Is a Unique Target for Therapeutic Intervention of Stroke","volume":"9","author":"Lin J.","year":"2017","journal-title":"International journal of physiology, pathophysiology and pharmacology"},{"key":"e_1_2_16_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/35097164"},{"key":"e_1_2_16_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ympev.2019.04.011"},{"key":"e_1_2_16_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u201094\u2010007\u20100265\u20103_12"},{"key":"e_1_2_16_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u201094\u2010007\u20100265\u20103_13"},{"key":"e_1_2_16_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2014.10.008"},{"key":"e_1_2_16_45_1","first-page":"49","volume-title":"Vascular Pharmacology","author":"Ghosh D.","year":"2017"},{"key":"e_1_2_16_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.048"},{"key":"e_1_2_16_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3343"},{"key":"e_1_2_16_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400745"},{"key":"e_1_2_16_49_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010neuro\u2010090919\u2010022842"},{"key":"e_1_2_16_50_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1807\u201059322011001300002"},{"key":"e_1_2_16_51_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R112.411645"},{"key":"e_1_2_16_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.09.029"},{"key":"e_1_2_16_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-34891-7_35"},{"key":"e_1_2_16_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00318"},{"key":"e_1_2_16_55_1","doi-asserted-by":"publisher","DOI":"10.1159\/000093042"},{"key":"e_1_2_16_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9010126"},{"key":"e_1_2_16_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108464"},{"key":"e_1_2_16_58_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.026906"},{"key":"e_1_2_16_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2127"},{"key":"e_1_2_16_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14215"},{"key":"e_1_2_16_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16111535"},{"key":"e_1_2_16_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113722"},{"key":"e_1_2_16_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.03.021"},{"key":"e_1_2_16_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020\u2010021\u201000545\u20109"},{"key":"e_1_2_16_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.635659"},{"key":"e_1_2_16_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424\u2010015\u20101764\u20107"},{"key":"e_1_2_16_67_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay3302"},{"key":"e_1_2_16_68_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.66709"},{"key":"e_1_2_16_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.05.069"},{"key":"e_1_2_16_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13113"},{"key":"e_1_2_16_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2024.150128"},{"key":"e_1_2_16_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00238"},{"issue":"1","key":"e_1_2_16_73_1","article-title":"Ion Channels Alterations in the Forebrain of High\u2010Fat Diet Fed Rats","volume":"65","author":"Roy P.","year":"2021","journal-title":"European Journal of Histochemistry"},{"key":"e_1_2_16_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051712"},{"key":"e_1_2_16_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03477"},{"key":"e_1_2_16_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.09.025"},{"key":"e_1_2_16_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2012.04.014"},{"key":"e_1_2_16_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2006.11.002"},{"key":"e_1_2_16_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.136"},{"key":"e_1_2_16_80_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43165"},{"key":"e_1_2_16_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105026"},{"key":"e_1_2_16_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121871"},{"key":"e_1_2_16_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv188"},{"key":"e_1_2_16_84_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.116.236695"},{"key":"e_1_2_16_85_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3764193"},{"key":"e_1_2_16_86_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.114.096008"},{"key":"e_1_2_16_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e16910"},{"key":"e_1_2_16_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.01.014"},{"key":"e_1_2_16_89_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202052013"},{"key":"e_1_2_16_90_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbaf153"},{"key":"e_1_2_16_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017\u2010021\u201008675\u2010x"},{"key":"e_1_2_16_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12535"},{"key":"e_1_2_16_93_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00638.2016"},{"key":"e_1_2_16_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u201094\u2010007\u20100265\u20103_31"},{"key":"e_1_2_16_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23265"},{"key":"e_1_2_16_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-34891-7_16"},{"key":"e_1_2_16_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112781"},{"key":"e_1_2_16_98_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlaa134"},{"key":"e_1_2_16_99_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.001032"},{"key":"e_1_2_16_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456\u2010011\u20109242\u20100"},{"key":"e_1_2_16_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010019\u201003124\u20102"},{"key":"e_1_2_16_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2016.06.008"},{"key":"e_1_2_16_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011\u2010022\u201003518\u20107"},{"key":"e_1_2_16_104_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.63040"},{"key":"e_1_2_16_105_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.771575"},{"key":"e_1_2_16_106_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.35316"},{"key":"e_1_2_16_107_1","doi-asserted-by":"publisher","DOI":"10.1080\/19336950.2021.1908781"},{"key":"e_1_2_16_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0896\u20106273(01)00240\u20109"},{"key":"e_1_2_16_109_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201696369"},{"key":"e_1_2_16_110_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000573"},{"key":"e_1_2_16_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.03.061"},{"key":"e_1_2_16_112_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242015415"},{"key":"e_1_2_16_113_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00138"},{"key":"e_1_2_16_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22081"},{"key":"e_1_2_16_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.07.049"},{"key":"e_1_2_16_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-0828-6_3"},{"key":"e_1_2_16_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2004.12.003"},{"key":"e_1_2_16_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.06.017"},{"key":"e_1_2_16_119_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11030322"},{"key":"e_1_2_16_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2020.104783"},{"key":"e_1_2_16_121_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells7070082"},{"key":"e_1_2_16_122_1","doi-asserted-by":"publisher","DOI":"10.1080\/19336950.2015.1075675"},{"key":"e_1_2_16_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00232\u2010023\u201000277\u2010x"},{"key":"e_1_2_16_124_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.160314"},{"key":"e_1_2_16_125_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5779\u201012.2013"},{"key":"e_1_2_16_126_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00251"},{"key":"e_1_2_16_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.12.056"},{"key":"e_1_2_16_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u201094\u2010024\u20101088\u20104_8"},{"key":"e_1_2_16_129_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8428"},{"key":"e_1_2_16_130_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00607.2013"},{"key":"e_1_2_16_131_1","doi-asserted-by":"publisher","DOI":"10.1080\/23262133.2017.1283187"},{"key":"e_1_2_16_132_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.45590"},{"key":"e_1_2_16_133_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology12040629"},{"key":"e_1_2_16_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.108617"},{"key":"e_1_2_16_135_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2274\u201013.2014"},{"key":"e_1_2_16_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.03.039"},{"key":"e_1_2_16_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70618"},{"key":"e_1_2_16_138_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1568145"},{"key":"e_1_2_16_139_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.37703"},{"key":"e_1_2_16_140_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5830\u201009.2010"},{"key":"e_1_2_16_141_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay6350"},{"key":"e_1_2_16_142_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4081\u201014.2015"},{"key":"e_1_2_16_143_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1120033109"},{"key":"e_1_2_16_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2025.110764"},{"key":"e_1_2_16_145_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010021\u201001170\u2010y"},{"key":"e_1_2_16_146_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adh0102"},{"key":"e_1_2_16_147_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13209"},{"key":"e_1_2_16_148_1","doi-asserted-by":"crossref","unstructured":"J.Wang L.Chen Z.Wang et\u00a0al. \u201cTRPC3 Suppression Ameliorates Synaptic Dysfunctions and Memory Deficits in Alzheimer's Disease \u201d bioRxiv Prepr. Serv. Biol September (2024) https:\/\/doi.org\/10.1101\/2024.09.16.611061.","DOI":"10.1101\/2024.09.16.611061"},{"key":"e_1_2_16_149_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010018\u20101258\u20107"},{"key":"e_1_2_16_150_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.70207"},{"key":"e_1_2_16_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1870"},{"key":"e_1_2_16_152_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22042074"},{"key":"e_1_2_16_153_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.118.114348"},{"key":"e_1_2_16_154_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1729\u201013.2013"},{"key":"e_1_2_16_155_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640\u2010022\u201000622\u20103"},{"key":"e_1_2_16_156_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2025.1534379"},{"key":"e_1_2_16_157_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010020\u201001012\u2010z"},{"key":"e_1_2_16_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.08.163"},{"key":"e_1_2_16_159_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.259875"},{"key":"e_1_2_16_160_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115672050286225231230130613"},{"key":"e_1_2_16_161_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242317097"},{"key":"e_1_2_16_162_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00403"},{"key":"e_1_2_16_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010021\u201000268\u20104"},{"key":"e_1_2_16_164_1","doi-asserted-by":"publisher","DOI":"10.1369\/00221554241246032"},{"key":"e_1_2_16_165_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.14073"},{"key":"e_1_2_16_166_1","doi-asserted-by":"publisher","DOI":"10.3390\/biotech10030014"},{"key":"e_1_2_16_167_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.315"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.70248","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcpt.70248","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.70248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:33:33Z","timestamp":1782102813000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.70248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,28]]},"references-count":166,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/bcpt.70248"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.70248","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,28]]},"assertion":[{"value":"2025-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70248"}}