{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:17:19Z","timestamp":1780917439039,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","award":["MJFF\u2010023918"],"award-info":[{"award-number":["MJFF\u2010023918"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A French signal detection study identified an association between sulfonamide diuretics use, particularly furosemide, and lower Parkinson's disease (PD) risk. Our aim was to confirm this association in a Finnish nationwide nested case\u2013control study (FINPARK), primarily in an indication\u2010restricted case\u2013control study of persons with heart or renal failure. Altogether 19\u2009568 PD cases diagnosed in 1999\u20132015 and 130\u2009156 age, sex and region\u2010matched controls were included. The case\u2013control study restricted to those with heart or renal failure included 1222 PD cases and 4766 matched controls. Furosemide use was identified from Prescription Register (1995\u20132015). The main analysis considered exposure at least 3\u2009years before the matching date (3\u2010year lag). Additional analyses with no lag, 5\u2010 and 8\u2010year lags were conducted. Furosemide was not associated with PD risk (adjusted OR, 95% CI 1.00, 0.87\u20131.15 for user\u2013non\u2010user comparison with 3\u2010year lag). A statistically significant borderline association between higher exposure levels and lower PD risk was observed in comparing risk across categories of cumulative furosemide exposure (adjusted OR, 95% CI 0.80, 0.64\u20131.00 with 3\u2010year lag). Our nationwide indication\u2010restricted case\u2013control study of persons with PD found no robust evidence on the association between furosemide use and PD risk. However, there was suggestive evidence of reduced risk for participants in the highest exposure category.<\/jats:p>","DOI":"10.1111\/bcpt.70249","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T03:41:13Z","timestamp":1779421273000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Furosemide and Risk of Parkinson's Disease in a Nested Case\u2013Control Study"],"prefix":"10.1111","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3999-6709","authenticated-orcid":false,"given":"Barkat","family":"Babar","sequence":"first","affiliation":[{"name":"School of Pharmacy University of Eastern Finland  Kuopio Finland"},{"name":"Kuopio Research Center of Geriatric Care University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0313-7080","authenticated-orcid":false,"given":"Anne","family":"Paakinaho","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Eastern Finland  Kuopio Finland"},{"name":"Kuopio Research Center of Geriatric Care University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3018-5507","authenticated-orcid":false,"given":"Emeline","family":"Courtois","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, UVSQ, Inserm CESP, High\u2010Dimensional Biostatistics for Drug Safety and Genomics  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabell","family":"Rumrich","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Eastern Finland  Kuopio Finland"},{"name":"Department of Public Health Finnish National Institute for Health and Welfare (THL)  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanis","family":"Saidi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, UVSQ, Inserm CESP, High\u2010Dimensional Biostatistics for Drug Safety and Genomics  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9724-5490","authenticated-orcid":false,"given":"Alexis","family":"Elbaz","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, UVSQ, Inserm, Gustave Roussy, CESP, Exposome and Heredity  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2651-2795","authenticated-orcid":false,"given":"Anne C. 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