{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:49:30Z","timestamp":1782103770510,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP25H00255"],"award-info":[{"award-number":["JP25H00255"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K17467"],"award-info":[{"award-number":["JP20K17467"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The effect of discrepancies in sampling time on the accuracy of area under the concentration\u2013time curve (AUC) estimation remains unclear. We evaluated how discrepancies between actual and recorded blood sampling times impact vancomycin AUC estimation using one\u2010point (trough) and two\u2010point (trough and peak) strategies in critically ill patients. In total, 25 patients at five Japanese hospitals were enrolled; 21 underwent sampling on Day 1 (AUC\n                    <jats:sub>day1<\/jats:sub>\n                    ) and 14 on Days 3\u20135 (AUC\n                    <jats:sub>ss<\/jats:sub>\n                    ). Reference AUCs were calculated using trapezoidal methods. Bayesian forecasting estimated AUCs from one\u2010 or two\u2010point sampling. Systematic trough (\u2264\u20094\u2009h earlier) and peak (\u22121 to +4\u2009h) time discrepancies were introduced. Predictive performance was defined as estimated\/reference AUC ratios within an acceptable range of 0.9\u20131.1. For AUC\n                    <jats:sub>day1<\/jats:sub>\n                    , two\u2010point sampling was more robust to trough discrepancies than one\u2010point sampling (acceptable interquartile range [IQR] up to 105 vs. 30\u2009min) but highly sensitive to peak timing (acceptable IQR \u221220 and +10\u2009min). For AUC\n                    <jats:sub>ss<\/jats:sub>\n                    , similar trends were observed. Overall, two\u2010point sampling offers superior robustness against trough discrepancies. However, because peak sampling is highly sensitive to timing errors, if the exact peak sampling time cannot be verified, clinicians may consider remeasuring the concentration or switching to one\u2010point trough sampling.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.70254","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:08:44Z","timestamp":1780531724000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantifying the Impact of Discrepancies Between Actual and Recorded Blood Sampling Times on Bayesian Forecasting for Area Under the Concentration\u2013Time Curve Estimation of Vancomycin"],"prefix":"10.1111","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8993-4333","authenticated-orcid":false,"given":"Tomoyuki","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Pharmacy Osaka Medical and Pharmaceutical University Hospital  Takatsuki City Osaka Japan"},{"name":"Infection Control Center Osaka Medical and Pharmaceutical University Hospital  Takatsuki City Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0693-1896","authenticated-orcid":false,"given":"Kazutaka","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Kumamoto University Hospital  Kumamoto City Kumamoto Japan"},{"name":"Department of Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences Kumamoto University  Kumamoto City Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5897-3739","authenticated-orcid":false,"given":"Yoko","family":"Hiyama","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima City Hiroshima Japan"},{"name":"Department of Pharmaceutical Services Hiroshima University Hospital  Hiroshima City Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5176-9050","authenticated-orcid":false,"given":"Takashi","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Infection Prevention and Control Hyogo Medical University Hospital  Nishinomiya City Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Furusho","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Japanese Red Cross Kumamoto Hospital  Kumamoto City Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Katanoda","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Kumamoto University Hospital  Kumamoto City Kumamoto Japan"},{"name":"Department of Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences Kumamoto University  Kumamoto City Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9118-0411","authenticated-orcid":false,"given":"Takashi","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Services Hiroshima University Hospital  Hiroshima City Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8730-5389","authenticated-orcid":false,"given":"Hiroaki","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Services Hiroshima University Hospital  Hiroshima City Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Ide","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Hyogo Medical University  Nishinomiya City Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Jingami","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Japanese Red Cross Kumamoto Hospital  Kumamoto City Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7551-0864","authenticated-orcid":false,"given":"Yusuke","family":"Kusaka","sequence":"additional","affiliation":[{"name":"Infection Control Center Osaka Medical and Pharmaceutical University Hospital  Takatsuki City Osaka Japan"},{"name":"Department of Intensive Care Medicine Osaka Medical and Pharmaceutical University Hospital  Takatsuki City Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7977-7597","authenticated-orcid":false,"given":"Hirofumi","family":"Jono","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Kumamoto University Hospital  Kumamoto City Kumamoto Japan"},{"name":"Department of Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences Kumamoto University  Kumamoto City Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq146"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14030489"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp080434"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02042\u201017"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa303"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13626"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.02.029"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14844"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bcp.70002"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.70159"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11010096"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095\u2010024\u201003781\u20104"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010147\u20108\u2010200710160\u201000010"},{"key":"e_1_2_11_15_1","volume-title":"The 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