{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:49:22Z","timestamp":1782103762148,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003945","name":"Link\u00f6pings Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003945","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Zopiclone was recently identified as a frequent contributor to fatal drug\u2010intoxications in Sweden. However, characteristics of misuse and factors associated with prescribed use remain insufficiently described. Alprazolam has a more established misuse profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of the study was to describe and compare characteristics of fatal intoxications positive for zopiclone or alprazolam, focusing on prescription status and factors associated with prescribed drug use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fatal intoxications between 2012 and 2020 with zopiclone and\/or alprazolam in blood were identified using the Swedish Cause of Death Register and the Swedish forensic medicine database. Prescriptions within 1 year before death, and health and sociodemographic data were obtained from national registers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1270 zopiclone cases, 84% were prescribed users compared to 22% of 1532 alprazolam cases. For both substances, prescribed use was associated with female sex (zopiclone: aOR = 1.68, 95% CI = 1.22\u20132.30; alprazolam: aOR = 2.04, 95% CI = 1.54\u20132.71), suicide relative to accidental intoxication (zopiclone: aOR = 1.61, 95% CI = 1.11\u20132.33; alprazolam: aOR = 3.21, 95% CI = 2.16\u20134.75) and age \u2265\u200946\u2009years (zopiclone: aOR = 2.26, 95% CI = 1.45\u20133.54; alprazolam: aOR = 3.20, 95% CI = 2.29\u20134.46). Psychiatry\u2010contact and previous self\u2010harm were associated with prescribed zopiclone use, but not alprazolam.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fatal intoxications involving zopiclone differ from alprazolam. While factors associated with prescribed use were often shared, substance\u2010specific preventative strategies could be beneficial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcpt.70256","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:09:41Z","timestamp":1780549781000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prescribing Patterns in Fatal Intoxications Involving Zopiclone and Alprazolam: An Observational Register\u2010Based Study"],"prefix":"10.1111","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2590-1852","authenticated-orcid":false,"given":"Lova","family":"Tralla","sequence":"first","affiliation":[{"name":"Division of Clinical Chemistry and Pharmacology, Department of Biomedical and Clinical Sciences Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"Department of Forensic Genetics and Forensic Toxicology National Board 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