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BCRP inhibition increases rosuvastatin plasma concentrations and may result in concentration\u2010dependent muscle toxicity, at worst rhabdomyolysis. We investigated if concomitant use of rosuvastatin and drugs identified as in\u00a0vitro BCRP inhibitors shows an increased number of rhabdomyolysis events based on pharmacovigilance data. From reports in the US Food and Drug Administration Adverse Event Reporting System for patients using rosuvastatin, we formed interaction (rosuvastatin with inhibitor) and non\u2010interaction (rosuvastatin without inhibitor) groups for 71 BCRP inhibitors. These groups were further divided into subgroups with or without rhabdomyolysis. For each inhibitor, we calculated reporting odds ratio (ROR) and 95% confidence intervals (CIs). We identified 9777 individual rosuvastatin\u2010related reports during 2013\u20132023, including 815 rhabdomyolysis reports. Of the 71 inhibitors, 19 had enough reports for analysis. Significantly increased RORs were obtained for the clinical BCRP inhibitors febuxostat (ROR 2.47, 95% CI 1.38\u20134.43) and ticagrelor (ROR 4.15, 95% CI 3.32\u20135.20). Amiodarone, erlotinib and rifampicin showed significantly increased RORs. Our findings support known interactions involving febuxostat and ticagrelor and suggest that also other BCRP inhibitors may increase the risk of rosuvastatin\u2010induced rhabdomyolysis.<\/jats:p>","DOI":"10.1111\/bcpt.70271","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:47:15Z","timestamp":1783072035000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Using Pharmacovigilance Data for Signal Detection of Drug Interactions for Rosuvastatin"],"prefix":"10.1111","volume":"139","author":[{"given":"Ronja","family":"Levom\u00e4ki","sequence":"first","affiliation":[{"name":"Pharmaceutical Sciences Laboratory, Department of Natural and Health Sciences, the Faculty of Science and Engineering \u00c5bo Akademi University  Turku 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