{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:03:58Z","timestamp":1784693038675,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007246","name":"Y\u00fcksek\u00f6\u011fretim Kurulu","doi-asserted-by":"publisher","award":["100\/2000"],"award-info":[{"award-number":["100\/2000"]}],"id":[{"id":"10.13039\/501100007246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The aim of this study was to investigate the effects of co\u2010exposure to perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) on the IL\u201017\u2010related immune responses and the Poly(I:C)\u2010induced lung inflammation. A total of 66 adult male BALB\/c mice were divided into 11 groups, including controls, dose groups receiving PFOS+PFOA (1, 3, 9\u2009mg\/kg\/day), and combination groups challenged with intratracheal Poly(I:C). Immunological responses were evaluated using flow cytometry, RT\u2010qPCR and ELISA assays. Poly(I:C) stimulation increased Th1, Th17 and Th22 cell percentages, consistent with immune activation. PFOS+PFOA exposure attenuated these responses in a dose\u2010dependent manner under Poly(I:C) (+) conditions. Conversely, increased Th2 cell percentages were observed in PFOS+PFOA exposure groups. Gene expression analyses of\n                    <jats:italic>Stat3<\/jats:italic>\n                    ,\n                    <jats:italic>Il17ra<\/jats:italic>\n                    and\n                    <jats:italic>Ror\u2010\u03b3t<\/jats:italic>\n                    further suggested tissue\u2010level modulation of IL\u201017\u2010related signalling pathways. Overall, PFOS+PFOA exposure may modulate the pulmonary immune microenvironment and alter Th1\/Th17\/Th22\u2010associated responses to Poly(I:C)\u2010induced inflammatory stimulation. These findings suggest that PFAS mixtures may influence pulmonary immune regulation under inflammatory conditions and support the inclusion of immune endpoints in PFAS toxicological evaluation.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.70272","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T03:48:47Z","timestamp":1783741727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of the Effects of Perfluorooctane Sulfonic Acid (PFOS) and Perfluorooctanoic Acid (PFOA) Exposure on Interleukin\u201017 Signalling and Poly(I:C)\u2010Induced Lung Inflammation in BALB\/c Mice"],"prefix":"10.1111","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7032-1537","authenticated-orcid":false,"given":"Eda Nur","family":"\u0130nkaya","sequence":"first","affiliation":[{"name":"Hacettepe University Department of Biology, Faculty of Science  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9735-968X","authenticated-orcid":false,"given":"Se\u00e7il","family":"Karahisar Turan","sequence":"additional","affiliation":[{"name":"Hacettepe University Department of Biology, Faculty of Science  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8657-2058","authenticated-orcid":false,"given":"Nurhayat","family":"Barlas","sequence":"additional","affiliation":[{"name":"Hacettepe University Department of Biology, Faculty of Science  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ieam.258"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0EM00291G"},{"key":"e_1_2_11_4_1","volume-title":"EPA CompTox Chemicals Dashboard","author":"EPA","year":"2026"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ieam.4735"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0800379"},{"key":"e_1_2_11_7_1","unstructured":"C8 Science Panel \u201cC8 Science Panel and the Probable Link Reports \u201d April 15 2012."},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/etc.4890"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00622-8"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41370-018-0094-1"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.8b04550"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.0c06978"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics11040325"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0244815"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.2034"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.106232"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12302-018-0134-4"},{"key":"e_1_2_11_18_1","volume-title":"Decision SC\u20104\/17. 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