{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:22:06Z","timestamp":1787552526068,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psychotropics are increasingly prescribed in paediatrics despite limited evidence regarding their benefits and effectiveness. Although deprescribing approaches are established in adults, structured paediatric strategies remain poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To identify and evaluate clinical practice guidelines (CPGs) on psychotropic deprescribing in youth, to describe and discuss recommendations regarding when and how to deprescribe in practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched PubMed, Embase, PsycInfo, Scopus, Web of Science and grey literature (2015\u20132025). Two reviewers independently screened and evaluated the quality of the guidelines (AGREE II). We derived from this a psychotropic deprescribing algorithm in youth, supplemented with clinical expertise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 1390 records identified, none strictly met the methodological criteria for formal CPGs. Nevertheless, we assessed two papers that provided practical deprescribing recommendations and shared several characteristics with CPGs. One systematic review focused on antidepressant discontinuation, recommending tapering after remission with gradual dose reduction and monitoring to distinguish withdrawal from relapse. One narrative review provided child\u2010specific guidance for stimulants, recommending reassessment and possible discontinuation after 1\u2009year of stability. Both were rated as \u2018moderate\u2019 using the AGREE II tool and provided limited practical detail on stepwise deprescribing procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Critical gap and urgent need for paediatric\u2010specific deprescribing guidelines. We propose an expert\u2010informed stepwise deprescribing algorithm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcpt.70278","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:27:02Z","timestamp":1784903222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deprescription of Psychotropics in Children and Adolescents: Systematic Review of Guidelines and Development of a Deprescribing Algorithm"],"prefix":"10.1111","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8558-4600","authenticated-orcid":false,"given":"Paul\u2010Beno\u00eet","family":"Fargier","sequence":"first","affiliation":[{"name":"Pharmacovigilance Centre Saint\u2010\u00c9tienne University Hospital  Saint\u2010\u00c9tienne France"},{"name":"Inserm Clinical Investigation Center (CIC\u2010EC 1408), North Hospital, Saint\u2010\u00c9tienne University Hospital  Saint\u2010\u00c9tienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1318-2029","authenticated-orcid":false,"given":"Mark","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Research and Development Department North East London NHS Foundation Trust  Ilford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9143-8291","authenticated-orcid":false,"given":"Rodolphe","family":"Charles","sequence":"additional","affiliation":[{"name":"Inserm Clinical Investigation Center (CIC\u2010EC 1408), North Hospital, Saint\u2010\u00c9tienne University Hospital  Saint\u2010\u00c9tienne France"},{"name":"Jacques\u2010Lisfranc Faculty of Medicine, Department of General Practice, Health and Innovation Campus Jean Monnet University  Saint\u2010Priest\u2010en\u2010Jarez France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Rousselon","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychopathology, Loire Autism Assessment Unit Saint\u2010\u00c9tienne University Hospital  Saint\u2010\u00c9tienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3522-4584","authenticated-orcid":false,"given":"Erik","family":"Fakra","sequence":"additional","affiliation":[{"name":"Inserm Clinical Investigation Center (CIC\u2010EC 1408), North Hospital, Saint\u2010\u00c9tienne University Hospital  Saint\u2010\u00c9tienne France"},{"name":"Department of Psychiatry Saint\u2010\u00c9tienne University Hospital  Saint\u2010\u00c9tienne France"},{"name":"Claude Bernard University Lyon 1, CNRS, INSERM, Lyon Neuroscience Research Center (CRNL), U1028 UMR 5292, PSYR2  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5831-8957","authenticated-orcid":false,"given":"Marie\u2010No\u00eblle","family":"Beyens","sequence":"additional","affiliation":[{"name":"Pharmacovigilance Centre Saint\u2010\u00c9tienne University Hospital  Saint\u2010\u00c9tienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4344-0359","authenticated-orcid":false,"given":"Marie\u2010Laure","family":"Laroche","sequence":"additional","affiliation":[{"name":"Centre of Pharmacovigilance and Pharmacoepidemiology Pharmacology, Toxicology and Pharmacovigilance Unit Limoges University Hospital  Limoges France"},{"name":"UR 24134 (VieSante), IFR OMEGA HEALTH, Limoges University  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010019\u201002711\u20103"},{"key":"e_1_2_11_3_1","volume-title":"Violence and Aggression: Short\u2010Term Management in Mental Health, Health and Community Settings: Updated Edition","author":"National Collaborating Centre for Mental Health (UK)","year":"2015"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013674.pub2"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008324.pub2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/00048674261418458"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787\u2010024\u201002502\u2010x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.156.7.696"},{"key":"e_1_2_11_9_1","unstructured":"\u201cOverview | Depression in Children and Young People: Identification and Management | Guidance | NICE \u201d NICE (2019) https:\/\/www.nice.org.uk\/guidance\/ng134."},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102023\u2010076733"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjqs\u20102019\u2010010033"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2023.115537"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2020.0095"},{"issue":"1","key":"e_1_2_11_14_1","first-page":"7","article-title":"Deprescribing Is an Essential Part of Good Prescribing","volume":"99","author":"Farrell B.","year":"2019","journal-title":"American Family Physician"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2010.0152"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018\u2010199410020\u201000002"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2025.116497"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000530692"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadr.2024.100765"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1192\/bja.2021.62"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000940"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbab017"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2018.11.030"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_25_1","unstructured":"AGREE Next Steps Consortium \u201cThe AGREE II Instrument (Electronic Version) \u201d Canada. [cited 2025 Feb 3] https:\/\/www.agreetrust.org\/wp\u2010content\/uploads\/2017\/12\/AGREE\u2010II\u2010Users\u2010Manual\u2010and\u201023\u2010item\u2010Instrument\u20102009\u2010Update\u20102017.pdf."},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcm.2016.02.012"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2024.0099"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010024\u201002445\u20104"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcz025"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506868"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215\u20100366(19)30032\u2010X"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2023.2224557"},{"key":"e_1_2_11_33_1","doi-asserted-by":"crossref","unstructured":"W.MorganandM.Baker \u201cEnsuring Appropriate Use of Psychotropic Medications in Pediatrics: Best Practices in Medication Discontinuation (Deprescribing) \u201d (2024):63\u201380 https:\/\/doi.org\/10.1007\/978\u20103\u2010031\u201057472\u20106_4.","DOI":"10.1007\/978-3-031-57472-6_4"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264\u2010022\u201001246\u20104"},{"issue":"1","key":"e_1_2_11_35_1","first-page":"60","article-title":"SSRIs and SNRIs: A Review of the Discontinuation Syndrome in Children and Adolescents","volume":"20","author":"Hosenbocus S.","year":"2011","journal-title":"Journal of the Canadian Academy of Child and Adolescent Psychiatry"},{"key":"e_1_2_11_36_1","volume-title":"The Maudsley Deprescribing Guidelines in Psychiatry: Antidepressants, Benzodiazepines, Gabapentinoids and Z\u2010drugs","author":"Horowitz M.","year":"2024"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/17423953060020020801"},{"key":"e_1_2_11_38_1","volume-title":"Depression in Adults: Treatment and Management","year":"2022"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/20451253231171518"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12267"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1003"},{"key":"e_1_2_11_42_1","volume-title":"Internet and Telephone Intervention to Support Patients Discontinuing Long\u2010Term Antidepressants in Primary Care: The REDUCE Research Programme Including RCT","author":"Kendrick T.","year":"2025"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045125320954609"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1521\/capn.2016.21.6.1"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/frcha.2024.1481446"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.9740\/mhc.2021.11.320"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2018.09.071"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbl.30216"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010017\u20100869\u2010x"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2026.10663"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40617\u2010022\u201000699\u20104"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010022\u201004479\u2010w"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14947"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0282988"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.70278","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcpt.70278","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.70278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:09:08Z","timestamp":1787551748000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.70278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/bcpt.70278"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.70278","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]},"assertion":[{"value":"2026-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70278"}}