{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:22:06Z","timestamp":1787552526020,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Vancomycin dosing is guided by population pharmacokinetic models that consider renal function. However, low serum creatinine (Scr) levels may reflect heterogeneous conditions and lead to inaccurate vancomycin clearance. This study evaluated the predictive ability of different population pharmacokinetic models for vancomycin clearance in low Scr settings. This single\u2010centre retrospective study included hospitalised patients aged \u226518\u2009years who received intravenous vancomycin. Predicted vancomycin clearance was calculated using population pharmacokinetic models across six scenarios incorporating creatinine clearance (Ccr), serum albumin, reduced muscle mass, Scr rounding and Japanese cystatin C\u2013based estimated glomerular filtration rate (eGFR\n                    <jats:sub>Japanese, Cys\u2010C<\/jats:sub>\n                    ). Agreement was evaluated using concordance correlation coefficients (CCC) and Bland\u2013Altman analysis. Among the six scenarios (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200924), the Ccr\u2010based model exhibited the best agreement (CCC\u2009=\u20090.79). Models based on eGFR\n                    <jats:sub>Japanese, Cys\u2010C<\/jats:sub>\n                    or rounded\u2010up Scr systematically underestimated clearance under augmented renal clearance. In those with a body mass index \u226525\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , clearance increased more substantially, and a similar trend was observed in patients aged &lt;70\u2009years. In patients with low Scr, Ccr\u2010based models showed better agreement with two\u2010point estimated vancomycin clearance. In obese or younger patients with low Scr, two\u2010point estimated vancomycin clearance may be a practical approach for vancomycin dosing.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.70287","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T07:58:08Z","timestamp":1787039888000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discrepancies in Vancomycin Clearance Estimation Among Renal Function Models in Patients With Low Serum Creatinine Levels: A Pilot Study"],"prefix":"10.1111","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0235-7615","authenticated-orcid":false,"given":"Yuki","family":"Nakano","sequence":"first","affiliation":[{"name":"Department of Pharmacy Saga University Hospital  Saga Japan"},{"name":"Department of Pharmacy Saiseikai Futsukaichi Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3898-2068","authenticated-orcid":false,"given":"Toshinori","family":"Hirai","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Institute of Science Tokyo Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7610-5920","authenticated-orcid":false,"given":"Rintaro","family":"Sogawa","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Saga University Hospital  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotsugu","family":"Hasuwa","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Saiseikai Futsukaichi Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3561-9538","authenticated-orcid":false,"given":"Chisato","family":"Shimanoe","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Saga University Hospital  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxaa036"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14030489"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04132-14"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12969"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.12.011"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000029"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0003202022"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339789"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.70159"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.541782.AD"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.07.007"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg349"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365510410003723"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2013.03.003"},{"key":"e_1_2_11_19_1","first-page":"61","article-title":"Functional Evaluation: The Barthel Index","volume":"14","author":"Mahoney F. 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