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The existing pharmaceutical treatments provide symptom management although they create important adverse effects and raise ongoing security concerns. Plant\u2010derived heterocyclic compounds present themselves as promising pharmaceutical substitution options because they demonstrate a wide spectrum of bioactivities that include anti\u2010inflammatory protection together with immunomodulatory and antioxidative properties. This review investigates the therapeutic properties of natural heterocyclic compounds principally including flavonoids, alkaloids, coumarins and terpenoids for RA treatment. Medical plants contain these abundant compounds that adjust inflammatory pathways consisting of NF\u2010\u03baB, MAPK and JAK\/STAT to decrease pro\u2010inflammatory cytokines TNF\u2010\u03b1, IL\u20101\u03b2 and IL\u20106 and restrict synovial fibroblast proliferation. The heterocyclic compounds found in medicinal plants also protect joints through two mechanisms: by improving antioxidant defences and activating cartilage repair. In addition to laboratory and animal test results the study evaluates how these natural compounds work together when combined in treatment plans. Research into structure\u2013activity interactions of heterocyclic compounds alongside their molecular targets enables better development of safe plant\u2010derived drugs. The research review demonstrates that plant\u2010derived heterocyclic compounds need to become essential components in treating RA while promoting clinical studies to determine their human subject action and mechanism of operation.<\/jats:p>","DOI":"10.1111\/bcpt.70292","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T07:17:38Z","timestamp":1787815058000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plant\u2010Derived Heterocyclic Compounds: A Promising Review on Natural Remedies for Rheumatoid Arthritis Management and Their Mechanistic Insights in Inflammation and Joint Protection"],"prefix":"10.1111","volume":"139","author":[{"given":"Jindong","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Clinical Medicine &amp; Laboratory Medicine, School of Chemistry and Chemical Engineering 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