{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:11:08Z","timestamp":1790154668114,"version":"4.0.1"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574420"],"award-info":[{"award-number":["82574420"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673486"],"award-info":[{"award-number":["81673486"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Diabetic kidney disease (DKD) is one of the most significant microvascular complications of diabetes, characterized by high incidence and mortality; however, its pathogenesis remains unclear. Renal inflammation and macrophage infiltration play pivotal roles in driving DKD progression. The transcription factor forkhead box protein O1 (FOXO1) regulates the transcriptional expression of multiple pro\u2010inflammatory molecules and modulates macrophage polarization. Nevertheless, its specific role in DKD macrophages remains unknown. In\u00a0vivo, streptozotocin\u2010induced DKD mice showed significantly higher FOXO1 expression in infiltrated kidney macrophages. Treatment with the FOXO1\u2010selective inhibitor AS1842856 for 4 or 12\u2009weeks reduced serum creatinine, blood urea nitrogen, renal matrix collagen deposition and the severity of macrophage infiltration in DKD mice. In\u00a0vitro, using mouse bone marrow\u2013derived macrophages and RAW264.7 cells cultured under high glucose, we found that high glucose promoted pro\u2010inflammatory M1 macrophage polarization. This polarization process was effectively blocked by either AS1842856 treatment or FOXO1 small interfering RNA\u2010mediated gene silencing. In summary, FOXO1 critically regulates macrophage infiltration and functional phenotype in DKD\u2010affected renal tissue. Targeting FOXO1 therefore holds promise as a potential therapeutic strategy to delay DKD progression.<\/jats:p>","DOI":"10.1111\/bcpt.70296","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T13:32:20Z","timestamp":1788442340000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Macrophage FOXO1 Inhibition Protects Against Hyperglycaemia\u2010Associated Kidney Injury"],"prefix":"10.1111","volume":"139","author":[{"given":"Hejie","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy Xinjiang Medical University, Key Laboratory of Natural Medicine Activity Components and Drug Release Technology in Xinjiang, Key Laboratory of the Ministry of Education in Xinjiang  Xinjiang China"},{"name":"Department of Pharmacology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling Peking University  Beijing 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