{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:09:51Z","timestamp":1790154591974,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Accurate documentation of drug allergies is critical to prevent re\u2010exposure while avoiding unnecessary restrictions on safe pharmacotherapy. Although true opioid hypersensitivity is rare, adverse effects are frequently misclassified as allergies. The aim of the present study was to evaluate opioid allergy registration across six Danish hospitals. All opioid allergy registrations between 2020 and 2023 were analysed using text\u2010mining algorithms. Registrations were dichotomised as \u2018probable allergy\u2019 or \u2018not allergy\u2019 based on predefined keywords and validated by manual journal audit. Among 1\u2009199\u2009314 patients, there were 14\u2009661 allergy registrations towards an opioid. Only 19% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092710) of the allergy registrations were classified as probable allergies, predominantly driven by rash and\/or pruritus (71%). The likelihood of an allergy registration being \u2018probable\u2019 was universally low, although slightly higher for intravenously administered opioids compared with orally administered morphine (OR\u2009=\u20090.26, 95% CI: 0.21; 0.32) and tramadol (OR\u2009=\u20090.36, 95% CI: 0.25; 0.46). The audit of 203 allergy registrations corroborated the text\u2010mining results. Notably, 63 patients (33%) received the same opioid despite a registered allergy. Opioid allergy registrations frequently misrepresent expected adverse drug reactions as true hypersensitivity, particularly for oral formulations. Improved diagnostic differentiation and documentation accuracy are imperative to optimise patient pain management protocols in hospitals.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.70300","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T08:30:13Z","timestamp":1789547413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Opioid Allergy Registrations in Danish Electronic Health Records: A Multihospital Register\u2010Based Study With Journal Audit"],"prefix":"10.1111","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5487-8359","authenticated-orcid":false,"given":"Andreas Halgreen","family":"Eiset","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"},{"name":"Department of Anaesthesia, Surgery, and Intensive Care Regionshospitalet Horsens  Horsens Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe Hertz","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Buttrup","family":"Rosenquist","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3612-5828","authenticated-orcid":false,"given":"Kenneth","family":"Skov","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Zealand University Hospital  K\u00f8ge Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7777-4501","authenticated-orcid":false,"given":"Lene Heise","family":"Garvey","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Allergy Clinic, Department of Dermatology and Allergy Copenhagen University Hospital\u2010Herlev and Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2560-1705","authenticated-orcid":false,"given":"Peter Gaarsdal","family":"Uhrbrand","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Anesthesiology and Intensive Care Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4905-1004","authenticated-orcid":false,"given":"Eva Aggerholm","family":"S\u00e6dder","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.61409\/V04240265"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.03.035"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028019860521"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.70182"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012509.pub2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2019.06.001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/acref\/9780199976720.001.0001"},{"key":"e_1_2_9_9_1","volume-title":"Kortl\u00e6gning af Opioidforbruget i 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