{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:11:31Z","timestamp":1790154691086,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Diabetic cardiomyopathy (DCM) is a major complication of diabetes mellitus, with limited therapeutic strategies available. Cuproptosis, a novel form of copper\u2010dependent cell death, has been implicated in cardiac dysfunction but remains unexplored in DCM. Here, we investigated the effects of Eriocitrin, a natural flavonoid, on DCM and examined the potential involvement of copper homeostasis, cuproptosis\u2010associated molecular alterations and SIRT7\/YAP\/ATP7A signalling. Using high\u2010fat diet and streptozotocin\u2010induced diabetic mice, along with high\u2010glucose\u2010treated cardiomyocytes, we demonstrated that Eriocitrin improved cardiac function, attenuated myocardial remodelling and corrected glucose and lipid metabolism. Mechanistically, Eriocitrin improved myocardial copper homeostasis by enhancing ATP7A and ATP7B expression and reducing copper accumulation and cuproptosis\u2010associated molecular alterations. Loss of SIRT7 impaired these effects, suggesting that SIRT7\u2010associated YAP\/ATP7A signalling contributes to Eriocitrin\u2010mediated cardioprotection. The therapeutic efficacy of Eriocitrin showed similar protective trends to tetrathiomolybdate, a copper chelator. These findings suggest that Eriocitrin alleviates experimental DCM in association with improved myocardial copper homeostasis and attenuation of cuproptosis\u2010associated molecular alterations, with SIRT7\u2010associated YAP\/ATP7A signalling potentially contributing to these effects.<\/jats:p>","DOI":"10.1111\/bcpt.70301","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:13:36Z","timestamp":1789460016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Eriocitrin Attenuates Diabetic Cardiomyopathy by Regulating Copper Homeostasis and Cuproptosis\u2010Associated Pathways via SIRT7\/YAP\/ATP7A Signalling"],"prefix":"10.1111","volume":"139","author":[{"given":"Lin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Sir Run Shaw Hospital, Zhejiang University School of Medicine  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixin","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Radiology Shanghai Jiading District Anting Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Functional Examination Shanghai Jiading District Anting Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingyong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cell Therapy Platform, Public Technology Platform, Institute of Health and Medicine Hefei Comprehensive National Science Center  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6871-8649","authenticated-orcid":false,"given":"Zixia","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Diagnosis Shanghai Jiading District Anting Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.2147\/DMSO.S302466","article-title":"Yes\u2010Associated Protein Is Involved in Myocardial Fibrosis in Rats With Diabetic Cardiomyopathy","volume":"14","author":"Hu M.","year":"2021","journal-title":"Diabetes, Metabolic Syndrome and Obesity: Targets and 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B.Yang U.Simonsen andJ.Lykkesfeldt \u201cBCPT Perspectives on Studies Involving Natural Products Traditional Chinese Medicine and Systems Pharmacology \u201d135 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