{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:54:47Z","timestamp":1790949287502,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["4308\u201000095B"],"award-info":[{"award-number":["4308\u201000095B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cystitis is common during pregnancy and requires effective antibiotic treatment to prevent complications. Gastric bypass surgery alters gastrointestinal anatomy and may impair oral drug absorption, raising concerns about antibiotic effectiveness. We therefore aimed to examine antibiotic use for cystitis and the risk of treatment failure in pregnant women with prior gastric bypass. In this nationwide Danish register\u2010based study, we compared 1985 pregnancies among women with prior gastric bypass with 1\u2009400\u2009174 pregnancies among women without bariatric surgery. We assessed redeemed prescriptions for cystitis\u2010related antibiotics and potential treatment failure defined as repeated antibiotic prescriptions within 14\u2009days, hospital\u2010recorded cystitis or severe urinary tract complications (pyelonephritis or urosepsis). Pregnant women with prior gastric bypass more frequently redeemed cystitis\u2010related antibiotics than those without bariatric surgery (22.6% vs. 12.7%). Among antibiotic\u2010exposed pregnancies, prior gastric bypass was associated with an increased risk of potential treatment failure, including repeated antibiotic prescriptions (adjusted odds ratio [aOR] 1.69, 95% confidence interval [CI] 1.22\u20132.30) and hospital\u2010recorded cystitis (aOR 2.22, 95% CI 1.24\u20133.67), while severe complications were rare. These findings suggest that antibiotic treatment may be less effective or that the clinical course is more complicated in this group, highlighting a need for closer monitoring and tailored treatment strategies.<\/jats:p>","DOI":"10.1111\/bcpt.70311","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:04:15Z","timestamp":1790946255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antibiotic Use for Cystitis and Risk of Treatment Failure in Pregnancy Following Gastric Bypass: A Cohort Study"],"prefix":"10.1111","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7180-3180","authenticated-orcid":false,"given":"Mette \u00d8stergaard","family":"Thunbo","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3739-8564","authenticated-orcid":false,"given":"Line","family":"Kolding","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Azuz","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0165-6994","authenticated-orcid":false,"given":"Terese Matthesen","family":"Kamronn","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"H\u00f8imark","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6726-1991","authenticated-orcid":false,"given":"Lars Henning","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"issue":"6","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1111\/aogs.14805","article-title":"Use of Medication in Pregnancy on the Rise: Study on 1.4 Million Danish Pregnancies From 1998 to 2018","volume":"103","author":"Thunbo M.","year":"1998","journal-title":"Acta Obstetricia et Gynecologica Scandinavica"},{"issue":"4","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/phar.70010","article-title":"A Review of Antibiotic Safety in Pregnancy\u20142025 Update","volume":"45","author":"Nguyen J.","year":"2025","journal-title":"Pharmacotherapy"},{"issue":"1","key":"e_1_2_12_4_1","article-title":"Urinary Tract Infection in Pregnancy and Its Effects on Maternal and Perinatal Outcome: A Retrospective Study","volume":"14","author":"Balachandran L.","year":"2022","journal-title":"Cureus"},{"issue":"2","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ogc.2007.03.002","article-title":"The Increasing Prevalence of Diabetes in Pregnancy","volume":"34","author":"Hunt K. J.","year":"2007","journal-title":"Obstetrics and Gynecology Clinics of North America"},{"issue":"2","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","DOI":"10.23889\/ijpds.v9i2.2401","article-title":"Global Trends in Prevalence of Maternal Overweight and Obesity: A Systematic Review and Meta\u2010Analysis of Routinely Collected Data Retrospective Cohorts","volume":"9","author":"Kent L.","year":"2024","journal-title":"International Journal of Population Data Science"},{"issue":"2","key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1258\/om.2009.090009","article-title":"Obesity in Pregnancy: Risks and Management","volume":"2","author":"Fitzsimons K. J.","year":"2009","journal-title":"Obstetric Medicine"},{"issue":"3","key":"e_1_2_12_8_1","doi-asserted-by":"crossref","DOI":"10.1002\/hsr2.605","article-title":"Drug Absorption in Bariatric Surgery Patients: A Narrative Review","volume":"5","author":"Alalwan A. 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