{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:48:48Z","timestamp":1792043328232,"version":"4.4.0"},"reference-count":65,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102026\u201025481749"],"award-info":[{"award-number":["RS\u20102026\u201025481749"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chemotherapy\u2010induced peripheral neuropathy (CIPN) adversely affects treatment efficacy and quality of life. Despite studies on glutathione (GSH) or GSH boosters' antioxidative effects for prevention, optimal management remains uncertain. We conducted a systematic review and network meta\u2010analysis of randomized controlled trials to consolidate and critically appraise the current evidence and to compare the efficacy of GSH and GSH boosters for the prevention of CIPN. The MEDLINE, Embase and CENTRAL databases were searched through March 2025. Twenty\u2010five RCTs involving 1625 patients were included. No intervention significantly reduced all\u2010grade CIPN compared with placebo.\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetylcysteine (odds ratio [OR] 0.19, 95% credible intervals [CrI] 0.05\u20130.63), GSH (OR 0.34, 95% CrI 0.13\u20130.79) and vitamin E (OR 0.33, 95% CrI 0.11\u20130.91) were associated with a reduced incidence of grade 3\/4 CIPN compared with placebo.\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetylcysteine ranked highest for both all\u2010grade and grade 3\/4 CIPN prevention. These findings remained consistent in sensitivity analyses excluding patients with pre\u2010existing neuropathy but were not retained in analyses restricted to double\u2010blind studies. Overall,\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetylcysteine, GSH, and vitamin E were associated with potential reductions in severe CIPN, with\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetylcysteine consistently ranking highest, although these associations should be regarded as preliminary. Further rigorously conducted and adequately powered trials are warranted to confirm these findings and evaluate agents demonstrating potential benefits.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.70319","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:29:46Z","timestamp":1792042186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evidence on Glutathione and Boosters for Prevention of Chemotherapy\u2010Induced Neuropathy: A Systematic Review and Network Meta\u2010Analysis"],"prefix":"10.1111","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8493-4078","authenticated-orcid":false,"given":"Min Jung","family":"Geum","sequence":"first","affiliation":[{"name":"College of Pharmacy and Institute of Pharmaceutical Science and Technology Hanyang University  Ansan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyoung","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Medicine and Regulatory Science, College of Medicine and Pharmacy Yonsei University  Incheon Republic of Korea"},{"name":"Department of Pharmacy National Cancer Center Hospital  Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JinYoung","family":"Moon","sequence":"additional","affiliation":[{"name":"Graduate Program of Industrial Pharmaceutical Sciences Yonsei University  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5676-3846","authenticated-orcid":false,"given":"Hyun Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Medicine and Regulatory Science, College of Medicine and Pharmacy Yonsei University  Incheon Republic of Korea"},{"name":"Department of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy Yonsei University  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy Yonsei University  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8267-9453","authenticated-orcid":false,"given":"Yun Mi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Medicine and Regulatory Science, College of Medicine and Pharmacy Yonsei University  Incheon Republic of Korea"},{"name":"Department of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy Yonsei University  Incheon Republic of Korea"},{"name":"Yonsei\u2010SL Bigen Research Institute, College of Pharmacy Yonsei University  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1607-9828","authenticated-orcid":false,"given":"Young\u2010Mi","family":"Ah","sequence":"additional","affiliation":[{"name":"College of Pharmacy Yeungnam University  Gyeongsan Republic of 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