{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T08:36:27Z","timestamp":1793003787741,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102026\u201025481749"],"award-info":[{"award-number":["RS\u20102026\u201025481749"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102026\u201025498607"],"award-info":[{"award-number":["RS\u20102026\u201025498607"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We investigated the effects of angiotensin II receptor blockers (ARBs) on the progression of Alzheimer's disease (AD). This retrospective cohort study used data from the Korean nationwide claims data to identify patients with AD aged 60\u201379\u2009years in 2010. ARB users and nonusers were 1:1 propensity score matched. Cox proportional hazards regression evaluated AD progression, defined as memantine initiation and mortality. Active\u2010comparator and dose\u2013response analyses were conducted. ARB use was associated with lower risks of memantine initiation (hazard ratio [HR]\u2009=\u20090.79; 95% confidence interval [CI]\u2009=\u20090.70\u20130.89) and mortality (HR\u2009=\u20090.83; 95% CI\u2009=\u20090.76\u20130.89). Cumulative exposure analyses showed stronger associations in the highest exposure categories, including\u20092\u20133\u2009years of ARB use and \u2265\u20092 DDD\u2010years, whereas associations in the lower exposure categories were not statistically significant. In active\u2010comparator analyses, ARBs were associated with lower mortality risk than ACE inhibitors and beta\u2010blockers, but not with dihydropyridine calcium channel blockers (CCBs). ARB use may be a reasonable antihypertensive choice in patients with AD, although the comparable outcomes between ARBs and CCBs suggest that these associations may not be unique to ARBs and may instead reflect shared blood pressure\u2013lowering and vascular effects. Further prospective research is warranted to optimize antihypertensive selection in patients with AD.<\/jats:p>","DOI":"10.1111\/bcpt.70323","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T09:09:23Z","timestamp":1792487363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Angiotensin II Receptor Blockers and the Risk of Alzheimer's Disease Progression: A Population\u2010Based Cohort Study"],"prefix":"10.1111","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5676-3846","authenticated-orcid":false,"given":"Hyun Woo","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Medicine and Regulatory Science, Colleges of Medicine and Pharmacy Yonsei University  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3327-3534","authenticated-orcid":false,"given":"Seungyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy Dankook University  Cheonan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0187-8440","authenticated-orcid":false,"given":"Byoung Seok","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine Yonsei University  Seoul Republic of Korea"},{"name":"Metabolism\u2010Dementia Research Institute Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8267-9453","authenticated-orcid":false,"given":"Yun Mi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Medicine and Regulatory Science, Colleges of Medicine and Pharmacy Yonsei University  Incheon Republic of Korea"},{"name":"Yonsei\u2010SL Bigen Research Institute, College of Pharmacy Yonsei University  Incheon Republic of Korea"},{"name":"Department of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy Yonsei University  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70235"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40259\u2010023\u201000633\u20102"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232213954"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30367\u20106"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2020.01.026"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(19)30393\u2010X"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000086"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1137197"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.19378"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b5465"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.02.011"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883\u2010023\u201003353\u2010w"},{"key":"e_1_2_11_14_1","unstructured":"WHO Collaborating Centre for Drug Statistics MethodologyATC Classification Index With DDDs 2024 (Oslo Norway: WHO Collaborating Centre for Drug Statistics Methodology 2024)2024Oslo NorwayWHO Collaborating Centre for Drug Statistics Methodology2024"},{"key":"e_1_2_11_15_1","unstructured":"Drugs.com \u201cMemantine: Package Insert\/Prescribing Information.\u201d"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201008595\u20101"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.17480\/psk.2022.66.5.225"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010210544"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(10)61349\u20109"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010024\u201001436\u20105"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15767"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.0580"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.2307\/2670170"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.70159"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010021\u201000778\u20108"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.06.007"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(21)00263\u20105"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac270"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.837890"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102012\u2010121090"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.70075"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.49370"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010020\u201000231\u2010y"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447\u20100594.2012.00900.x"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41709"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010181035"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X16666180828100002"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.136879"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313260"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17049"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.70323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcpt.70323","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.70323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T08:15:53Z","timestamp":1793002553000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.70323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,20]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/bcpt.70323"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.70323","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,20]]},"assertion":[{"value":"2026-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70323"}}