{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:46:29Z","timestamp":1773294389990,"version":"3.50.1"},"reference-count":76,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T00:00:00Z","timestamp":1353456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>Li C\u2010T, Hsieh J\u2010C, Wang S\u2010J, Yang B\u2010H, Bai Y\u2010M, Lin W\u2010C, Lan C\u2010C, Su T\u2010P. Differential relations between fronto\u2010limbic metabolism and executive function in patients with remitted bipolar I and bipolar II disorder. \u2028Bipolar Disord 2012: 14: 831\u2013842. \u00a9 2012 John Wiley &amp; Sons A\/S. Published by Blackwell Publishing Ltd.<\/jats:p><jats:p><jats:bold>Objectives:<\/jats:bold> The aim of this study was to investigate the relationship between resting brain glucose metabolism and cognitive profiles in patients with remitted bipolar I disorder (BD\u2010I) and bipolar II disorder (BD\u2010II). We hypothesized that BD\u2010I patients (compared to BD\u2010II patients) would perform worse on tests of cognitive function because of abnormal metabolism in the prefrontal cortex and other mood\u2010related brain areas.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Thirty\u2010four patients with remitted bipolar disorder (BD) (BD\u2010I\u2003=\u200317, BD\u2010II\u2003=\u200317) under treatment and 17 well\u2010matched healthy controls received both fluorodeoxyglucose (<jats:sup>18<\/jats:sup>F\u2010FDG) positron emission tomography (PET) and neuropsychological tests of attention, memory, and executive function.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Clinical features in patients with BD\u2010I and BD\u2010II were comparable. Executive function, as indicated by performance on the Wisconsin Card Sorting Test, was significantly worse (i.e., higher percentage of errors, lower percentage of conceptual level responses, and fewer categories completed) in BD\u2010I patients than in BD\u2010II patients and healthy subjects. No difference in attention and memory tests was found among these three groups. Brain PET analysis showed that BD\u2010I patients (compared to BD\u2010II patients) had significantly lower glucose uptake in the bilateral anterior cingulum, insula, striatum, and part of the prefrontal cortex, and higher glucose uptake in the left parahippocampus. Further analyses revealed significant correlations between poor executive function and abnormal glucose uptake in other brain areas in BD\u2010I patients.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> There are neurobiological differences between subtypes of BD. BD\u2010I is associated with more impaired fronto\u2010limbic circuitry, which might account for reduced executive function in BD\u2010I patients during remission.<\/jats:p>","DOI":"10.1111\/bdi.12017","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T11:37:30Z","timestamp":1353497850000},"page":"831-842","source":"Crossref","is-referenced-by-count":43,"title":["Differential relations between fronto\u2010limbic metabolism and executive function in patients with remitted bipolar I and bipolar II 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