{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:47:41Z","timestamp":1767984461159,"version":"3.49.0"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T00:00:00Z","timestamp":1361750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p><jats:bold>Objectives:\u2002<\/jats:bold> Despite growing attention to the relationship between bipolar disorder (BD) and quality of life (QoL), there remains a lack of information about QoL in the early stages of BD, and about the course of QoL in people with BD over time. Here, we report on QoL and symptomatic outcomes over a 1.5\u2010year period in a Canadian sample of first\u2010episode mania patients.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Patients (n\u2003=\u200363) with DSM\u2010IV\u2010TR BD type I recovering from a recent episode of mania were recruited from a university\u2010based hospital setting in Vancouver, BC, Canada and assessed at six monthly intervals for 18\u2003months. In addition to symptomatic and cognitive assessments, two self\u2010report QoL scales [the Quality of Life Enjoyment and Satisfaction Questionnaire (Q\u2010LES\u2010Q) and the Medical Outcomes Study Short Form 36 (SF\u201036)] were administered.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Baseline QoL scores were high, with mean Q\u2010LES\u2010Q scores at 70% of the maximum possible score; QoL continued to show a trend towards improvement over time. Multiple hierarchical regressions were used to explore predictors of QoL over time, finding that: (i) length of illness and severity of depressive symptoms at baseline predicted Q\u2010LES\u2010Q scores at both baseline and six months; (ii) the number of previous depressive episodes and severity of depression at baseline and 12\u2003months all predicted QoL at 12\u2003months; and (iii) only severity of depressive symptoms at 12\u2003months predicted QoL at 18\u2003months.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Our observation that QoL in patients who have recently experienced an episode of mania can be relatively preserved offers hope, both for healthcare providers and for those newly diagnosed. Further, that severity of depressive symptoms even in the early stages of the disease was the consistent predictor of QoL suggests that depressive symptoms need to be aggressively treated to improve QoL.<\/jats:p>","DOI":"10.1111\/bdi.12049","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T15:56:42Z","timestamp":1361807802000},"page":"188-198","source":"Crossref","is-referenced-by-count":26,"title":["The relationship between clinical outcomes and quality of life in first\u2010episode mania: a longitudinal analysis"],"prefix":"10.1111","volume":"15","author":[{"given":"Erin E","family":"Michalak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan J","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J","family":"Bond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond W","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi N","family":"Yatham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,25]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(95)00112-K"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12016"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2005.08.001"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n0205"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/comp.2001.23143"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2006.07.007"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(87)90009-7"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-008-0034-1"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/10673220701679804"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.2.220"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.55.1.49"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-3-72"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200822050-00003"},{"key":"e_1_2_7_15_2","volume-title":"Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.; DSM\u2010IV\u2010TR)","year":"2000"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00672.x"},{"key":"e_1_2_7_17_2","first-page":"22","article-title":"The Mini\u2010International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM\u2010IV and ICD\u201010","volume":"59","author":"Sheehan DV","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2005.00219.x"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800320058007"},{"key":"e_1_2_7_21_2","volume-title":"California Verbal Learning Test","author":"Delis DC","year":"2000"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04997yel"},{"key":"e_1_2_7_23_2","first-page":"321","article-title":"Quality of Life Enjoyment and Satisfaction Questionnaire: a new measure","volume":"29","author":"Endicott J","year":"1993","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_7_24_2","unstructured":"WareJ SnowKK KonsinkiM GandekB.SF\u201036 Health Survey: manual and interpretation guide. 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