{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:45:45Z","timestamp":1791308745285,"version":"4.3.1"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T00:00:00Z","timestamp":1364947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Early identification of bipolar disorder (\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      ) symptomatology is crucial for improving the prognosis of this illness. Increased mood lability has been reported in\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      . However, mood lability is ubiquitous across psychiatric disorders and may be a marker of severe psychopathology and not specific to\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      . To clarify this issue, this study examined the prevalence of mood lability and its components in offspring of\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      parents and offspring of community control parents recruited through the Pittsburgh Bipolar Offspring Study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Forty\u2010one school\u2010age\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      offspring of 38\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      parents, 257 healthy or non\u2010\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      offspring of 174\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      parents, and 192 offspring of 117 control parents completed a scale that was developed to evaluate mood lability in youth, i.e., the Children's Affective Lability Scale (\n                      <jats:styled-content style=\"fixed-case\">CALS<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A factor analysis of the parental\n                      <jats:styled-content style=\"fixed-case\">CALS<\/jats:styled-content>\n                      , and in part the child\n                      <jats:styled-content style=\"fixed-case\">CALS<\/jats:styled-content>\n                      , revealed\n                      <jats:italic>Irritability<\/jats:italic>\n                      ,\n                      <jats:italic>Mania<\/jats:italic>\n                      , and\n                      <jats:italic>Anxiety\/Depression<\/jats:italic>\n                      factors, with most of the variance explained by the\n                      <jats:italic>Irritability<\/jats:italic>\n                      factor. After adjusting for confounding factors (e.g., parental and offspring non\u2010\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      psychopathology),\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      offspring of\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      parents showed the highest parental and child total and factor scores, followed by the non\u2010\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      offspring of\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      parents, and then the offspring of the controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Mood lability overall and mania\u2010like, anxious\/depressed, and particularly irritability symptoms may be a prodromal phenotype of\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      among offspring of parents with\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      . Prospective studies are warranted to clarify whether these symptoms will predict the development of\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      and\/or other psychopathology. If confirmed, these symptoms may become a target of treatment and biological studies before\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      develops.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.12060","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T03:07:05Z","timestamp":1364958425000},"page":"253-263","source":"Crossref","is-referenced-by-count":57,"title":["Mood lability among offspring of parents with bipolar disorder and community controls"],"prefix":"10.1111","volume":"15","author":[{"given":"Boris","family":"Birmaher","sequence":"first","affiliation":[{"name":"Department of Psychiatry Western Psychiatric Institute and Clinic University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin 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