{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:07Z","timestamp":1787013907335,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T00:00:00Z","timestamp":1375747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Since there is a worldwide steady increase in the number of individuals living longer and an expected increase in the number of older adults who will be diagnosed with bipolar disorder, there is a growing need to better understand late\u2010life mania. We provide in this review a report of published studies focusing on the prevalence of late\u2010life mania in the community and in senior psychiatric care facilities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a search of PubMed and Psychinfo databases using combinations of the keywords\n                      <jats:italic>bipolar<\/jats:italic>\n                      ,\n                      <jats:italic>manic\/a<\/jats:italic>\n                      ,\n                      <jats:italic>manic depression<\/jats:italic>\n                      ,\n                      <jats:italic>elderly<\/jats:italic>\n                      , and\n                      <jats:italic>older<\/jats:italic>\n                      including\n                      <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\n                      nglish\u2010language reports presenting quantitative data on the prevalence of mania in adults over the age of 50\u00a0years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighteen out of 188 potentially eligible studies met our inclusion criteria, with most studies focusing on psychiatric inpatient samples. The overall prevalence of late\u2010life mania was estimated to be 6.0% in the reported 1,519 older psychiatric inpatients. In elderly inpatients with bipolar disorder, the mean prevalence of late\u2010onset mania was 44.2%. For other relevant care facilities, no firm conclusions could be drawn.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Late\u2010life mania is not rare in older psychiatric inpatients and late\u2010onset mania is associated with increased somatic comorbidity in patients aged 50\u00a0years and older. Several hypotheses regarding the relationship between somatic illness and late\u2010life mania in the elderly have been proposed and studies on this relationship and the prevalence of late\u2010life mania in different senior psychiatric care facilities deserve specific attention in future research projects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.12104","type":"journal-article","created":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T05:40:36Z","timestamp":1375767636000},"page":"113-118","source":"Crossref","is-referenced-by-count":58,"title":["The prevalence of late\u2010life mania: a review"],"prefix":"10.1111","volume":"16","author":[{"given":"Annemiek","family":"Dols","sequence":"first","affiliation":[{"name":"Department of Old Age Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph W","family":"Kupka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry GGZ inGeest VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"van Lammeren","sequence":"additional","affiliation":[{"name":"Department of Old Age Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aartjan T","family":"Beekman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry GGZ inGeest VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Sajatovic","sequence":"additional","affiliation":[{"name":"University Hospitals Case Medical Center Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max L","family":"Stek","sequence":"additional","affiliation":[{"name":"Department of Old Age Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,6]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Manic\u2010Depressive Illness. 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