{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T20:48:31Z","timestamp":1779396511411,"version":"3.53.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T00:00:00Z","timestamp":1375920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the present study was to assess the effect of aspirin on lithium\u2010related sexual dysfunction in men with stable bipolar affective disorder (<jats:styled-content style=\"fixed-case\">BAD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a randomized, double\u2010blind, placebo\u2010controlled study, 32 men with stable <jats:styled-content style=\"fixed-case\">BAD<\/jats:styled-content> who had been on lithium maintenance therapy randomly received aspirin (240\u00a0mg\/day) or placebo for six weeks. The International Index for Erectile Function (<jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content>) was used to assess sexual symptoms at baseline, Week 3, and Week 6. Depressive and mania symptoms and plasma lithium concentrations were assessed at baseline and Week 6. Side effects were assessed using a checklist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty patients (15\/group) completed the study. Baseline and endpoint lithium concentrations and mania and depressive symptoms did not differ significantly between the two groups. Significant effects of time\u00a0\u00d7\u00a0treatment interaction were observed for total score [Greenhouse\u2013Geisser: <jats:italic>F<\/jats:italic>(1.410,39.466)\u00a0=\u00a06.084, p\u00a0=\u00a00.010] and erectile function [Greenhouse\u2013Geisser: <jats:italic>F<\/jats:italic>(1.629,45.602)\u00a0=\u00a07.250, p\u00a0=\u00a00.003]. By Week 6, patients in the aspirin group showed significantly greater improvement in the total (63.9% improvement from the baseline) and erectile function domain (85.4% improvement from the baseline) scores than the placebo group (14.4% and 19.7% improvement from the baseline, p\u2010values\u00a0=\u00a00.002 and 0.001, respectively). By Week 6, 12 (80%) patients in the aspirin group and three (20%) patients in the placebo group met the criteria of minimal clinically important change [\u03c7<jats:sup>2<\/jats:sup>(1)\u00a0=\u00a010.800, p\u00a0=\u00a00.001]. Other <jats:styled-content style=\"fixed-case\">IIEF<\/jats:styled-content> domains also showed significant improvement at the end of the trial. The frequency of side effects was similar between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Aspirin effectively improves lithium\u2010related sexual dysfunction in men with stable <jats:styled-content style=\"fixed-case\">BAD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12108","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T07:27:05Z","timestamp":1375946825000},"page":"650-656","source":"Crossref","is-referenced-by-count":52,"title":["Aspirin for treatment of lithium\u2010associated sexual dysfunction in men: randomized double\u2010blind placebo\u2010controlled study"],"prefix":"10.1111","volume":"15","author":[{"given":"Sepideh","family":"Saroukhani","sequence":"first","affiliation":[{"name":"Psychiatric Research Center Roozbeh Hospital Tehran University of Medical Sciences Tehran 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