{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:45:14Z","timestamp":1792205114721,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T00:00:00Z","timestamp":1376352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Depressive and anxiety disorders are common in youth who are at risk for bipolar disorder (i.e., youth who have at least one parent with bipolar disorder) and antidepressants are commonly prescribed as treatment. However, there are few data regarding the safety and tolerability of antidepressants in this population. Therefore, we sought to prospectively examine the effects of these medications in children and adolescents who are diagnosed with depressive or anxiety disorders and have a parent with bipolar I disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Youth aged 9\u201320\u00a0years, with at least one parent with bipolar I disorder [high risk (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      )], were recruited (n\u00a0=\u00a0118) and assessed using semi\u2010structured diagnostic interviews. Participants were prospectively evaluated using a modified version of the Longitudinal Interval Follow\u2010up Evaluation to assess changes in affective and anxiety symptoms and were treated naturalistically.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over the course of 43\u2013227\u00a0weeks (mean duration of follow\u2010up: 106\u00a0\u00b1\u00a055\u00a0weeks), 21% (n\u00a0=\u00a025) of youth had antidepressant exposure and, of these, 57% (n\u00a0=\u00a012) had an adverse reaction (e.g., irritability, aggression, impulsivity, or hyperactivity) that led to antidepressant discontinuation. Those patients who experienced an adverse reaction were significantly younger than those who did not (p\u00a0=\u00a00.02) and discontinuation of antidepressant therapy secondary to an adverse event occurred at an average of 16.7\u00a0\u00b1\u00a017.4\u00a0weeks (median: 11\u00a0weeks, range: 2\u201357\u00a0weeks). Cox proportional hazard analyses yielded a hazard ratio of 0.725 (p\u00a0=\u00a00.03), suggesting that there is a 27% decrease in the likelihood of an antidepressant\u2010related adverse event leading to discontinuation with each one\u2010year increase in age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Antidepressant medications may be poorly tolerated in youth with a familial risk for developing mania. Controlled studies further assessing treatments for depression and anxiety in\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      youth are urgently needed.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.12113","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T07:18:50Z","timestamp":1376378330000},"page":"523-530","source":"Crossref","is-referenced-by-count":65,"title":["Antidepressant tolerability in anxious and depressed youth at high risk for bipolar disorder: a prospective naturalistic treatment study"],"prefix":"10.1111","volume":"16","author":[{"given":"Jeffrey R","family":"Strawn","sequence":"first","affiliation":[{"name":"Division of Bipolar Disorders Research Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb M","family":"Adler","sequence":"additional","affiliation":[{"name":"Division of Bipolar Disorders Research Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K","family":"McNamara","sequence":"additional","affiliation":[{"name":"Division of Bipolar Disorders Research Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A","family":"Welge","sequence":"additional","affiliation":[{"name":"Division of Bipolar Disorders Research Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha M","family":"Bitter","sequence":"additional","affiliation":[{"name":"Division of Bipolar Disorders Research Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil P","family":"Mills","sequence":"additional","affiliation":[{"name":"Division of Bipolar Disorders Research Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drew H","family":"Barzman","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Cerullo","sequence":"additional","affiliation":[{"name":"Division of Bipolar Disorders Research Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiki D","family":"Chang","sequence":"additional","affiliation":[{"name":"Pediatric Bipolar Disorders Program Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M","family":"Strakowski","sequence":"additional","affiliation":[{"name":"Division of Bipolar Disorders Research Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa P","family":"DelBello","sequence":"additional","affiliation":[{"name":"Division of Bipolar Disorders Research Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.5.497"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.20013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1982.04290050029007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200004000-00014"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.1.125"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.01.004"},{"key":"e_1_2_7_8_1","first-page":"16","article-title":"Bipolar disorder and comorbid anxiety disorders in children and adolescents","volume":"67","author":"Dineen Wagner K","year":"2006","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/chi.0b013e318145ae1c"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2005.01467.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.chi.0000246070.23695.06"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.21913"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chc.2012.05.003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1521\/psyc.66.4.317.25437"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.158.8.773"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(02)00180-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.06.010"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2003.12.011"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.06.016"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2008.018"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199908000-00010"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2165\/11591660-000000000-00000"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-200012000-00003"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2011.12.021"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2011.00890.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(98)00178-5"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0812"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n0519"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n0520"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.192"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.6.1098"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2008.81"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2006.11.006"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2010.00847.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.164.2.273"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804633"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.8.901"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.2165\/11539700-000000000-00000"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbdi.12113","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bdi.12113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T11:58:39Z","timestamp":1694433519000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bdi.12113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,13]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/bdi.12113"],"URL":"https:\/\/doi.org\/10.1111\/bdi.12113","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727686353.793532837","asserted-by":"object"}]},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,13]]}}}