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This article summarizes the phenomenology of bipolar disorder with an emphasis on the initial prodrome, the evolution of the illness, and the implications for prevention and early intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature review was undertaken using Medline, Web of Science, and a hand search of relevant literature using keywords (e.g., phenomenology, initial or early symptoms, risk factors, and predictors\/prediction). Findings from the literature were reviewed and synthesized and have been put into a clinical context.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bipolar disorder is a recurrent, persistent, and disabling illness that typically develops in adolescence or early adulthood. The literature search yielded 28 articles, in which mood lability, nonspecific, non\u2010mood symptoms, and cyclothymic temperament were the most cited prodromal features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A small number of key prospective studies have provided evidence in support of an initial bipolar prodrome; however, methodological differences across studies have prohibited its clear delineation. It is, therefore, not currently possible to anticipate those who will develop bipolar disorder solely on the basis of early phenomenology. Accurate characterization of the bipolar disorder prodrome through high\u2010quality, prospective research studies with adequate control groups will ultimately facilitate prompt and accurate diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12133","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T13:29:46Z","timestamp":1382707786000},"page":"455-470","source":"Crossref","is-referenced-by-count":44,"title":["Predicting bipolar disorder on the basis of phenomenology: implications for prevention and early intervention"],"prefix":"10.1111","volume":"16","author":[{"given":"Gin S","family":"Malhi","sequence":"first","affiliation":[{"name":"Department of Psychiatry CADE Clinic Royal North Shore Hospital Sydney NSW Australia"},{"name":"Discipline of Psychiatry Sydney Medical School University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle M","family":"Bargh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry CADE Clinic Royal North Shore Hospital Sydney NSW Australia"},{"name":"Discipline of Psychiatry Sydney Medical School University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carissa M","family":"Coulston","sequence":"additional","affiliation":[{"name":"Department of Psychiatry CADE Clinic Royal North Shore Hospital Sydney NSW Australia"},{"name":"Discipline of Psychiatry Sydney Medical School University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pritha","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Psychiatry CADE Clinic Royal North Shore Hospital Sydney NSW Australia"},{"name":"Discipline of Psychiatry Sydney Medical School University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Berk","sequence":"additional","affiliation":[{"name":"School of Medicine Deakin University Geelong Australia"},{"name":"Department of Psychiatry University of Melbourne Melbourne Australia"},{"name":"Orygen Research Centre Melbourne Australia"},{"name":"Mental Health Research Institute Parkville Vic. 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