{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T11:51:44Z","timestamp":1774007504270,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,10,9]],"date-time":"2013-10-09T00:00:00Z","timestamp":1381276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>There is a large body of evidence to indicate that neurocognitive impairments in bipolar disorder (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) may represent viable endophenotypes; however, a standard consensus\u2010based battery of cognitive tests used to measure them is yet to appear. There is potential for a neurocognitive battery which was developed for use in the related disorder, schizophrenia \u2013 the <jats:styled-content style=\"fixed-case\">MATRICS<\/jats:styled-content> Consensus Cognitive Battery (<jats:styled-content style=\"fixed-case\">MCCB<\/jats:styled-content>) \u2013 to provide a consistent measurement tool with a standard to which the cognitive capacity of <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> can be compared to other disorders. However, its suitability for capturing neurocognitive impairment in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> cohorts is not well established. Moreover, neurocognitive tests recently recommended by the International Society for Bipolar Disorders (<jats:styled-content style=\"fixed-case\">ISBD<\/jats:styled-content>) for inclusion in a consensus neurocognitive battery for <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> have not been evaluated in the context of the <jats:styled-content style=\"fixed-case\">MCCB<\/jats:styled-content>. An evaluation of (i) the clinical efficacy of the <jats:styled-content style=\"fixed-case\">MCCB<\/jats:styled-content> and (ii) the tests recommended by the <jats:styled-content style=\"fixed-case\">ISBD<\/jats:styled-content> in a <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> cohort were the aims of the current study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 50 patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> (mean age<jats:italic>\u00a0<\/jats:italic>=\u00a038\u00a0years) and 52 healthy controls (mean age\u00a0=\u00a034\u00a0years) completed all of the <jats:styled-content style=\"fixed-case\">MCCB<\/jats:styled-content> subtests, in addition to the well\u2010recognized Trail Making Test\u2013Part B and the Colour\u2013Word Stroop.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate analyses of variance of the <jats:styled-content style=\"fixed-case\">MCCB<\/jats:styled-content> domains revealed a significant group effect for overall cognition, and significantly reduced patient performance on speed of processing, working memory, and visual and verbal learning. A second multivariate analysis of variance using a newly created composite score called <jats:italic>executive function<\/jats:italic>, comprising scores on an existing <jats:styled-content style=\"fixed-case\">MCCB<\/jats:styled-content> subtest in addition to <jats:styled-content style=\"fixed-case\">TMT<\/jats:styled-content>\u2010B and Colour\u2013Word Stroop, revealed significant differences on this domain as well. Subgroup analysis indicated that there were no differences in any domain score performance between symptomatic and euthymic patients, or bipolar I and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> disorder patient groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that the <jats:styled-content style=\"fixed-case\">MCCB<\/jats:styled-content> and two additionally recommended <jats:styled-content style=\"fixed-case\">ISBD<\/jats:styled-content> executive function measures form a promising consensus\u2010based research tool for examining neurocognition in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12134","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:54:31Z","timestamp":1381542871000},"page":"318-325","source":"Crossref","is-referenced-by-count":79,"title":["An empirical evaluation of the <scp>MATRICS<\/scp> Consensus Cognitive Battery in bipolar disorder"],"prefix":"10.1111","volume":"16","author":[{"given":"Tamsyn E","family":"Van Rheenen","sequence":"first","affiliation":[{"name":"Brain and Psychological Sciences Research Centre Faculty of Life and Social Sciences Swinburne University of Technology Melbourne Vic. Australia"},{"name":"Monash Alfred Psychiatry Research Centre (MAPrc) The Alfred Hospital and Monash University Central Clinical School Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan L","family":"Rossell","sequence":"additional","affiliation":[{"name":"Brain and Psychological Sciences Research Centre Faculty of Life and Social Sciences Swinburne University of Technology Melbourne Vic. Australia"},{"name":"Monash Alfred Psychiatry Research Centre (MAPrc) The Alfred Hospital and Monash University Central Clinical School Melbourne Vic. 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