{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:22:13Z","timestamp":1790806933538,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T00:00:00Z","timestamp":1414108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council New Zealand","doi-asserted-by":"crossref","award":["03\/096B"],"award-info":[{"award-number":["03\/096B"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This randomized, controlled clinical trial compared the effect of interpersonal and social rhythm therapy (<jats:styled-content style=\"fixed-case\">IPSRT<\/jats:styled-content>) to that of specialist supportive care (<jats:styled-content style=\"fixed-case\">SSC<\/jats:styled-content>) on depressive outcomes (primary), social functioning, and mania outcomes over 26\u201378\u00a0weeks in young people with bipolar disorder receiving psychopharmacological treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects were aged 15\u201336\u00a0years, recruited from a range of sources, and the patient groups included bipolar I disorder, bipolar <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> disorder, and bipolar disorder not otherwise specified. Exclusion criteria were minimal. Outcome measures were the Longitudinal Interval Follow\u2010up Evaluation and the Social Adjustment Scale. Paired\u2010sample <jats:italic>t<\/jats:italic>\u2010tests were used to determine the significance of change from baseline to outcome period. Analyses of covariance were used to determine the impact of therapy, impact of lifetime and current comorbidity, interaction between comorbidity and therapy, and impact of age at study entry on depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A group of 100 participants were randomized to <jats:styled-content style=\"fixed-case\">IPSRT<\/jats:styled-content> (n\u00a0=\u00a049) or <jats:styled-content style=\"fixed-case\">SSC<\/jats:styled-content> (n\u00a0=\u00a051). The majority had bipolar I disorder (78%) and were female (76%), with high levels of comorbidity. After treatment, both groups had improved depressive symptoms, social functioning, and manic symptoms. Contrary to our hypothesis, there was no significant difference between therapies. There was no impact of lifetime or current Axis I comorbidity or age at study entry. There was a relative impact of <jats:styled-content style=\"fixed-case\">SSC<\/jats:styled-content> for patients with current substance use disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IPSRT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SSC<\/jats:styled-content> used as an adjunct to pharmacotherapy appear to be effective in reducing depressive and manic symptoms and improving social functioning in adolescents and young adults with bipolar disorder and high rates of comorbidity. Identifying effective treatments that particularly address depressive symptoms is important in reducing the burden of bipolar disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12273","type":"journal-article","created":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T05:53:17Z","timestamp":1414129997000},"page":"128-138","source":"Crossref","is-referenced-by-count":100,"title":["Randomized, controlled trial of Interpersonal and Social Rhythm Therapy for young people with bipolar disorder"],"prefix":"10.1111","volume":"17","author":[{"given":"Maree L","family":"Inder","sequence":"first","affiliation":[{"name":"Department of Psychological Medicine University of Otago, Christchurch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie T","family":"Crowe","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine University of Otago, Christchurch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne E","family":"Luty","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine University of Otago, Christchurch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet D","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine University of Otago, Christchurch"},{"name":"Department of Psychology University of Canterbury Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Moor","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine University of Otago, Christchurch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M","family":"Frampton","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine University of Otago, Christchurch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R","family":"Joyce","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine University of Otago, Christchurch"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.9.1636"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.3.420"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n0811"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(00)00247-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.6.530"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.155.5.646"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2004.00137.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/10673221003747955"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6394(1997)5:2<73::AID-DA3>3.0.CO;2-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2005.00207.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s127-002-8211-z"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.07.006"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2010.02.012"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.08040488"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00715.x"},{"key":"e_1_2_7_17_1","volume-title":"Manic\u2010Depressive Illness \u2013 Bipolar Disorders and Recurrent Depression","author":"Goodwin FK","year":"2007"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.9.996"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.07121953"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.4.419"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.07020311"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20668"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n0609"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.12.2222"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.107.040485"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2008.00588.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.2.145"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674370805300709"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1176\/ps.2006.57.7.959"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820080032005"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820080038006"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1987.01800180050009"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-200012000-00003"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1976.01770090101010"},{"key":"e_1_2_7_37_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1176\/ajp.151.12.1","article-title":"Practice guideline for the treatment of patients with bipolar disorder","volume":"151","author":"American Psychiatric Association","year":"1994","journal-title":"Am J Psychiatry"},{"key":"e_1_2_7_38_1","unstructured":"FrankE KupferDJ CornesC CarterSB FrankelD HlastalaSA.Interpersonal and Social Rhythm Therapy (IPSRT). A manual for the adaptation of interpersonal psychotherapy to the treatment of bipolar disorder. Presented at the Fourth International Conference on Bipolar Disorder June 14\u201316 2001 Pittsburgh PA."},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579406060615"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2008.02571.x"},{"key":"e_1_2_7_41_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.4.741"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.188.4.313"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c869"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-199304000-00005"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.15"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.12m08049"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.08101569"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.11.1635"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.2.217"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.09020299"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2007.05.014"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.104.007773"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20053"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.10.905"},{"issue":"3","key":"e_1_2_7_56_1","first-page":"11","article-title":"Optimizing treatment outcomes in bipolar disorder under ordinary conditions","volume":"69","author":"Goldberg JF","year":"2008","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13020225"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.08.011"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.4.402"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbdi.12273","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bdi.12273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:20:10Z","timestamp":1695561610000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bdi.12273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,24]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/bdi.12273"],"URL":"https:\/\/doi.org\/10.1111\/bdi.12273","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,24]]}}}