{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T06:41:16Z","timestamp":1780900876374,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T00:00:00Z","timestamp":1414713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","award":["IRUSQUET0413"],"award-info":[{"award-number":["IRUSQUET0413"]}],"id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Several lines of evidence suggest that abnormalities within portions of the extended limbic network involved in affective regulation and expression contribute to the neuropathophysiology of bipolar disorder. In particular, portions of the prefrontal cortex have been implicated in the appearance of manic symptomatology. The effect of atypical antipsychotics on activation of these regions, however, remains poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010two patients diagnosed with bipolar mania and 26 healthy subjects participated in a baseline functional magnetic resonance imaging scan during which they performed a continuous performance task with neutral and emotional distractors. Nineteen patients with bipolar disorder were treated for eight weeks with quetiapine monotherapy and then rescanned. Regional activity in response to emotional stimuli was compared between healthy and manic subjects at baseline; and in the subjects with bipolar disorder between baseline and eight\u2010week scans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, functional activity did not differ between subjects with bipolar disorder and healthy subjects in any region examined. After eight weeks of treatment, subjects with bipolar disorder showed a significant decrease in ratings on the Young Mania Rating Scale (<jats:styled-content style=\"fixed-case\">YMRS<\/jats:styled-content>) (p\u00a0&lt;\u00a00.001), and increased activation in the right orbitofrontal cortex (<jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>) (p\u00a0=\u00a00.002); there was a significant association between increased right <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> activity and <jats:styled-content style=\"fixed-case\">YMRS<\/jats:styled-content> improvement (p\u00a0=\u00a00.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings are consistent with suggestions that mania involves a loss of emotional modulatory activity in the prefrontal cortex\u2014restoration of the relatively greater elevation in prefrontal activity widely observed in euthymic patients is associated with clinical improvement. It is not clear, however, whether changes are related to quetiapine treatment or represent a non\u2010specific marker of affective change.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12274","type":"journal-article","created":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T08:30:24Z","timestamp":1414744224000},"page":"444-449","source":"Crossref","is-referenced-by-count":10,"title":["Neurofunctional effects of quetiapine in patients with bipolar mania"],"prefix":"10.1111","volume":"17","author":[{"given":"Andrew K","family":"Davis","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience Division of Bipolar Disorders Research University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa P","family":"DelBello","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience Division of Bipolar Disorders Research University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Eliassen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience Division of Bipolar Disorders Research University of Cincinnati College of Medicine Cincinnati OH USA"},{"name":"Center for Imaging Research University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Welge","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience Division of Bipolar Disorders Research University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J","family":"Blom","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience Division of Bipolar Disorders Research University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E","family":"Fleck","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience Division of Bipolar Disorders Research University of Cincinnati College of Medicine Cincinnati OH USA"},{"name":"Center for Imaging Research University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wade A","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience Division of Bipolar Disorders Research University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly B","family":"Jarvis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience Division of Bipolar Disorders Research University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Rummelhoff","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience Division of Bipolar Disorders Research University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M","family":"Strakowski","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience Division of Bipolar Disorders Research University of Cincinnati College of Medicine Cincinnati OH USA"},{"name":"Center for Imaging Research University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb M","family":"Adler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience Division of Bipolar Disorders Research University of Cincinnati College of Medicine 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