{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T18:29:15Z","timestamp":1792866555250,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T00:00:00Z","timestamp":1421366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Previous reviews have concluded that interventions including psychoeducation are effective in preventing relapse in bipolar disorder, but the efficacy of psychoeducation itself has not been systematically reviewed. Our aim was to evaluate the efficacy of psychoeducation for bipolar disorder in preventing relapse and other outcomes, and to identify factors that relate to clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We employed the systematic review of randomized controlled trials of psychoeducation in participants with bipolar disorder not in an acute illness episode, compared with treatment\u2010as\u2010usual, and placebo or active interventions. Pooled odds ratios (\n                      <jats:styled-content style=\"fixed-case\">ORs<\/jats:styled-content>\n                      ) for non\u2010relapse into any episode, mania\/hypomania, and depression were calculated using an intent\u2010to\u2010treat (\n                      <jats:styled-content style=\"fixed-case\">ITT<\/jats:styled-content>\n                      ) analysis, assigning dropouts to relapse, with a sensitivity analysis in which dropouts were assigned to non\u2010relapse (optimistic\n                      <jats:styled-content style=\"fixed-case\">ITT<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixteen studies were included, eight of which provided data on relapse. Although heterogeneity in the data warrants caution, psychoeducation appeared to be effective in preventing any relapse [n\u00a0=\u00a07;\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      : 1.98\u20132.75; number needed to treat (\n                      <jats:styled-content style=\"fixed-case\">NNT<\/jats:styled-content>\n                      ): 5\u20137, depending on the method of analysis] and manic\/hypomanic relapse (n\u00a0=\u00a08;\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      : 1.68\u20132.52;\n                      <jats:styled-content style=\"fixed-case\">NNT<\/jats:styled-content>\n                      : 6\u20138), but not depressive relapse. Group, but not individually, delivered interventions were effective against both poles of relapse; the duration of follow\u2010up and hours of therapy explained some of the heterogeneity. Psychoeducation improved medication adherence and short\u2010term knowledge about medication. No consistent effects on mood symptoms, quality of life, or functioning were found.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Group psychoeducation appears to be effective in preventing relapse in bipolar disorder, with less evidence for individually delivered interventions. Better understanding of mediating mechanisms is needed to optimize efficacy and personalize treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.12287","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T04:38:28Z","timestamp":1421383108000},"page":"349-362","source":"Crossref","is-referenced-by-count":147,"title":["Psychoeducation for relapse prevention in bipolar disorder: a systematic review of efficacy in randomized controlled trials"],"prefix":"10.1111","volume":"17","author":[{"given":"Kirsten","family":"Bond","sequence":"first","affiliation":[{"name":"Specialist Service for Affective Disorders Manchester Mental Health and Social Care Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M","family":"Anderson","sequence":"additional","affiliation":[{"name":"Neuroscience and Psychiatry Unit Institute of Brain, Behaviour and Mental Health University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e8508"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.187.6.559"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1192\/apt.bp.108.006403"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.158.2.197"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.4.402"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.07.016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3922\/j.psns.2011.3.014"},{"key":"e_1_2_8_9_1","first-page":"CD004854","article-title":"Interventions for helping people recognise early signs of recurrence in bipolar disorder","author":"Morriss RK","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00724.x"},{"key":"e_1_2_8_11_1","unstructured":"National Institute for Health and Clinical Excellence.Clinical Guideline 38. 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