{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:49:45Z","timestamp":1764251385165,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T00:00:00Z","timestamp":1424908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH086026"],"award-info":[{"award-number":["R01MH086026"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS16367"],"award-info":[{"award-number":["NS16367"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS32765"],"award-info":[{"award-number":["NS32765"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Huntington's disease is a neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms that are caused by huntingtin gene (<jats:styled-content style=\"fixed-case\"><jats:italic>HTT<\/jats:italic>) CAG<\/jats:styled-content> trinucleotide repeat alleles of 36 or more units. A greater than expected prevalence of incompletely penetrant <jats:italic><jats:styled-content style=\"fixed-case\">HTT<\/jats:styled-content><\/jats:italic> <jats:styled-content style=\"fixed-case\">CAG<\/jats:styled-content> repeat alleles observed among individuals diagnosed with major depressive disorder raises the possibility that another mood disorder, bipolar disorder, could likewise be associated with Huntington's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed the distribution of <jats:italic><jats:styled-content style=\"fixed-case\">HTT<\/jats:styled-content><\/jats:italic> <jats:styled-content style=\"fixed-case\">CAG<\/jats:styled-content> repeat alleles in a cohort of individuals with bipolar disorder. <jats:italic><jats:styled-content style=\"fixed-case\">HTT<\/jats:styled-content><\/jats:italic> <jats:styled-content style=\"fixed-case\">CAG<\/jats:styled-content> allele sizes from 2,229 Caucasian individuals diagnosed with <jats:styled-content style=\"fixed-case\">DSM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> bipolar disorder were compared to allele sizes in 1,828 control individuals from multiple cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that <jats:italic><jats:styled-content style=\"fixed-case\">HTT<\/jats:styled-content><\/jats:italic> <jats:styled-content style=\"fixed-case\">CAG<\/jats:styled-content> repeat alleles &gt; 35\u00a0units were observed in only one of 4,458 chromosomes from individuals with bipolar disorder, compared to three of 3,656 chromosomes from control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings do not support an association between bipolar disorder and Huntington's disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12289","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T16:07:23Z","timestamp":1424966843000},"page":"403-408","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence of Huntington's disease gene CAG trinucleotide repeat alleles in patients with bipolar disorder"],"prefix":"10.1111","volume":"17","author":[{"given":"Eliana Marisa","family":"Ramos","sequence":"first","affiliation":[{"name":"Center for Human Genetic Research Massachusetts General Hospital Boston MA USA"},{"name":"UnIGENe IBMC \u2013 Institute for Molecular and Cell Biology University of Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammy","family":"Gillis","sequence":"additional","affiliation":[{"name":"Center for Human Genetic Research Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayalakshmi S","family":"Mysore","sequence":"additional","affiliation":[{"name":"Center for Human Genetic Research Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong\u2010Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Human Genetic Research Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8549-6903","authenticated-orcid":false,"given":"Isabel","family":"Alonso","sequence":"additional","affiliation":[{"name":"UnIGENe IBMC \u2013 Institute for Molecular and Cell Biology University of Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F","family":"Gusella","sequence":"additional","affiliation":[{"name":"Center for Human Genetic Research Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan W","family":"Smoller","sequence":"additional","affiliation":[{"name":"Center for Human Genetic Research Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Sklar","sequence":"additional","affiliation":[{"name":"Division of Psychiatric Genomics Department of Psychiatry Mount Sinai School of Medicine New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcy E","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Center for Human Genetic Research Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy H","family":"Perlis","sequence":"additional","affiliation":[{"name":"Center for Human Genetic Research Massachusetts General Hospital Boston MA 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