{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T16:48:59Z","timestamp":1773334139230,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T00:00:00Z","timestamp":1429056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We tested the hypothesis that a common functional variant in brain\u2010derived neurotrophic factor (<jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content>), Val66Met, which has been shown to be associated with increased body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) in schizophrenia (<jats:styled-content style=\"fixed-case\">SCZ<\/jats:styled-content>) and schizoaffective disorder (<jats:styled-content style=\"fixed-case\">SAD<\/jats:styled-content>), is also associated with antipsychotic\u2010induced weight gain in bipolar disorder (<jats:styled-content style=\"fixed-case\">BPD<\/jats:styled-content>). Association of Val66Met with other metabolic measures, including high\u2010 and low\u2010density cholesterol, triglycerides, total cholesterol, fasting blood glucose, and hemoglobin A1c, was also tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a 12\u2010month, prospective, randomized trial of two atypical antipsychotic drugs (<jats:styled-content style=\"fixed-case\">APD<\/jats:styled-content>s) with moderate (risperidone) or high (olanzapine) risk to cause weight gain. Subjects were diagnosed as having <jats:styled-content style=\"fixed-case\">BPD<\/jats:styled-content> (n\u00a0=\u00a090) and <jats:styled-content style=\"fixed-case\">SCZ<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">SAD<\/jats:styled-content> (n\u00a0=\u00a076).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> was significantly greater in all diagnoses for Met66 allele carriers at six months (p\u00a0=\u00a00.01). Met66 carriers with <jats:styled-content style=\"fixed-case\">BPD<\/jats:styled-content> showed a greater increase in the triglycerides\/high\u2010density (<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>) cholesterol ratio (p\u00a0=\u00a00.01), a key marker for metabolic syndrome related to insulin resistance, and log\u2010triglycerides (p\u00a0=\u00a00.04), after three or six months of treatment. Met66 carriers had the greatest increase in log\u2010triglycerides (p\u00a0=\u00a00.03) and triglycerides\/<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> cholesterol ratio after three months of treatment with risperidone (p\u00a0=\u00a00.003), and the highest <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> at six months (p\u00a0=\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The positive association of <jats:styled-content style=\"fixed-case\">BNDF<\/jats:styled-content> Val66Met with high <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> values replicates previous findings in patients with <jats:styled-content style=\"fixed-case\">SCZ<\/jats:styled-content> and indicates the <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> Val66Met genotype as a potential risk factor for obesity and insulin resistance measures in patients with <jats:styled-content style=\"fixed-case\">BPD<\/jats:styled-content> receiving antipsychotics as well.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12294","type":"journal-article","created":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T12:13:23Z","timestamp":1429100003000},"page":"528-535","source":"Crossref","is-referenced-by-count":57,"title":["The brain\u2010derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with increased body mass index and insulin resistance measures in bipolar disorder and schizophrenia"],"prefix":"10.1111","volume":"17","author":[{"given":"Stefania","family":"Bonaccorso","sequence":"first","affiliation":[{"name":"Department of Psychosis Studies Institute of Psychiatry at the Maudsley King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monsheel","family":"Sodhi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice University of Illinois Chicago IL 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