{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:15:56Z","timestamp":1790518556060,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,4]],"date-time":"2015-04-04T00:00:00Z","timestamp":1428105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NARSAD Distinguished Investigator Grant 2012, Brain & Behavior Research Foundation, New York.","award":["19796"],"award-info":[{"award-number":["19796"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Life expectancy in patients with bipolar disorder has been reported to be decreased by 11 to 20\u00a0years. These calculations are based on data for individuals at the age of 15\u00a0years. However, this may be misleading for patients with bipolar disorder in general as most patients have a later onset of illness. The aim of the present study was to calculate the remaining life expectancy for patients of different ages with a diagnosis of bipolar disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using nationwide registers of all inpatient and outpatient contacts to all psychiatric hospitals in Denmark from 1970 to 2012 we calculated remaining life expectancies for values of age 15, 25, 35 \u20db 75 years among all individuals alive in year 2000.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the typical male or female patient aged 25 to 45\u00a0years, the remaining life expectancy was decreased by 12.0\u20138.7\u00a0years and 10.6\u20138.3\u00a0years, respectively. The ratio between remaining life expectancy in bipolar disorder and that of the general population decreased with age, indicating that patients with bipolar disorder start losing life\u2010years during early and mid\u2010adulthood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Life expectancy in bipolar disorder is decreased substantially, but less so than previously reported. Patients start losing life\u2010years during early and mid\u2010adulthood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12296","type":"journal-article","created":{"date-parts":[[2015,4,4]],"date-time":"2015-04-04T07:11:43Z","timestamp":1428131503000},"page":"543-548","source":"Crossref","is-referenced-by-count":193,"title":["Life expectancy in bipolar disorder"],"prefix":"10.1111","volume":"17","author":[{"given":"Lars Vedel","family":"Kessing","sequence":"first","affiliation":[{"name":"Psychiatric Center Copenhagen Department O University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Vradi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Kragh","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-0447.2003.00266.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.185.5.372"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2012.02.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.01024.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(02)00004-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.031773"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.111.101931"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.173.1.11"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(99)00191-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.9.844"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n0612"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019590"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.06.008"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067133"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.107.037820"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2013.08.007"},{"key":"e_1_2_9_18_1","first-page":"5","article-title":"Course of a clinical cohort of unipolar, bipolar and schizoaffective patients. Results of a prospective study from 1959 to 1985","volume":"146","author":"Angst J","year":"1995","journal-title":"Schweiz Arch Neurol Psychiatr"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291701004718"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2006.00278.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291704003307"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12058"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.2.307"},{"key":"e_1_2_9_24_1","first-page":"97","article-title":"Early age at onset as a risk factor for poor outcome of bipolar disorder","volume":"37","author":"Carter TD","year":"2003","journal-title":"J Psychiatr Res"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2005.00181.x"},{"key":"e_1_2_9_26_1","volume-title":"Manic Depressive Illness. Bipolar Disorder and Recurrent Depression","author":"Goodwin FK","year":"2007"},{"key":"e_1_2_9_27_1","first-page":"82","article-title":"The Danish Psychiatric Central Register","volume":"44","author":"Munk\u2010Jorgensen P","year":"1997","journal-title":"Dan Med Bull"},{"key":"e_1_2_9_28_1","volume-title":"Klassifikation af sygdomme. Systematisk del. International Statistical Classification of Diseases and Health Related Problems","author":"World Health Organisation","year":"1993"},{"key":"e_1_2_9_29_1","unstructured":"Statistics Denmark.Statistics Denmark 2014. Available from:http:\/\/www.dst.dk\/HomeUK.aspx[accessed March 2015]."},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-4348-9"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610202008517"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.111.092718"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0602"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08r04505"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.06.010"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.05.018"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.05.011"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12245"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.02.004"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbdi.12296","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bdi.12296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T14:28:37Z","timestamp":1696343317000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bdi.12296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,4]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/bdi.12296"],"URL":"https:\/\/doi.org\/10.1111\/bdi.12296","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,4]]}}}