{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T10:49:23Z","timestamp":1758970163208,"version":"3.37.3"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T00:00:00Z","timestamp":1433203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"Taiwan National Science Council","doi-asserted-by":"crossref","award":["NSC99-2627-B-006-015"],"award-info":[{"award-number":["NSC99-2627-B-006-015"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007750","name":"National Cheng Kung University","doi-asserted-by":"crossref","award":["Project for Promoting Academic Excellence and Developing World Class Research Centers"],"award-info":[{"award-number":["Project for Promoting Academic Excellence and Developing World Class Research Centers"]}],"id":[{"id":"10.13039\/501100007750","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Taiwan National Health Research Institute","award":["NHRI-EX99-9738NI"],"award-info":[{"award-number":["NHRI-EX99-9738NI"]}]},{"DOI":"10.13039\/501100001868","name":"Taiwan National Science Council","doi-asserted-by":"crossref","award":["NSC98-2627-B-006-017"],"award-info":[{"award-number":["NSC98-2627-B-006-017"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Objectives<\/jats:title>A high prevalence rate of bipolar disorder (BP<\/jats:styled-content>) comorbid with alcohol dependence (AD<\/jats:styled-content>) (BP<\/jats:styled-content>+AD<\/jats:styled-content>) in Western patients withBP<\/jats:styled-content>has been reported, but whether this is true for Han Chinese withBP<\/jats:styled-content>is uncertain. We explored the prevalence ofBP<\/jats:styled-content>+AD<\/jats:styled-content>in a Han Chinese population withBP<\/jats:styled-content>, and investigated the effect of alcohol\u2010metabolizing genotypes on bipolar I disorder (BP<\/jats:styled-content>\u2010I) +AD<\/jats:styled-content>and bipolarII<\/jats:styled-content>disorder (BP<\/jats:styled-content>\u2010II<\/jats:styled-content>) +AD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Healthy controls (HC<\/jats:styled-content>s) (n\u00a0=\u00a0672) and 18\u2010 to 65\u2010year\u2010old patients withBP<\/jats:styled-content>(BP<\/jats:styled-content>\u2010I: n\u00a0=\u00a0530;BP<\/jats:styled-content>\u2010II<\/jats:styled-content>: n\u00a0=\u00a0788) were recruited. Patients with any other major or minor mental illnesses, neurological disorders, or organic mental disorders were excluded. A polymerase chain reaction and restriction fragment length polymorphism analysis was used to determine genotypes for alcohol dehydrogenase 1B (ADH<\/jats:styled-content>1B) and aldehyde dehydrogenase 2 (ALDH<\/jats:styled-content>2), two alcohol\u2010metabolizing enzymes.<\/jats:p><\/jats:sec>Results<\/jats:title>AD<\/jats:styled-content>comorbidity rates were 11.7% withBP<\/jats:styled-content>\u2010I and 17.1% withBP<\/jats:styled-content>\u2010II<\/jats:styled-content>. Significantly fewer patients withBP<\/jats:styled-content>not comorbid withAD<\/jats:styled-content>(BP<\/jats:styled-content>\u2013AD<\/jats:styled-content>) carried theAHD<\/jats:styled-content>1B*1<\/jats:italic>allele than did theHC<\/jats:styled-content>s. Logistic regression analysis showed a main effect ofALDH<\/jats:styled-content>2*1\/*1<\/jats:italic>only in theBP<\/jats:styled-content>\u2010I\u2013AD<\/jats:styled-content>group. InBP<\/jats:styled-content>+AD<\/jats:styled-content>patients, logistic regression analysis showed main effects ofALDH<\/jats:styled-content>2*1\/*1<\/jats:italic>andADH<\/jats:styled-content>1B*1\/*1<\/jats:italic>only in theBP<\/jats:styled-content>\u2010II<\/jats:styled-content>+AD<\/jats:styled-content>group.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>HavingBP<\/jats:styled-content>\u2010II<\/jats:styled-content>+AD<\/jats:styled-content>may be related toALDH<\/jats:styled-content>2<\/jats:italic>andADH<\/jats:styled-content>1B<\/jats:italic>, but havingBP<\/jats:styled-content>\u2010I+AD<\/jats:styled-content>may be related only toALDH<\/jats:styled-content>2<\/jats:italic>. We conclude thatALDH<\/jats:styled-content>2<\/jats:italic>andADH<\/jats:styled-content>1B<\/jats:italic>have different effects in Han Chinese patients withBP<\/jats:styled-content>\u2010I+AD<\/jats:styled-content>andBP<\/jats:styled-content>\u2010II<\/jats:styled-content>+AD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12313","type":"journal-article","created":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T00:42:15Z","timestamp":1433292135000},"page":"536-542","source":"Crossref","is-referenced-by-count":8,"title":["Comorbid alcohol dependence disorder may be related to aldehyde dehydrogenase 2 (ALDH<\/scp>2<\/i>) and alcohol dehydrogenase 1B (ADH<\/scp>1B<\/i>) in bipolarII<\/scp>disorder, but only toALDH<\/scp>2<\/i>in bipolar I disorder, in Han Chinese"],"prefix":"10.1111","volume":"17","author":[{"given":"Yun\u2010Hsuan","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Clinical Psychology Institute of Allied Health Sciences Tainan Taiwan"},{"name":"Department of Psychiatry College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Department of Psychology Asia University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng\u2010Yu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry National Cheng Kung University Hospital Tainan Taiwan"},{"name":"Department of Psychiatry Kaohsiung Veteran's General Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu\u2010Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Department of Psychiatry National Cheng Kung University Hospital Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiou\u2010Lan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nian\u2010Sheng","family":"Tzeng","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Tri\u2010Service General Hospital National Defense Medical Center Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po See","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Department of Psychiatry National Cheng Kung University Hospital Tainan Taiwan"},{"name":"Addiction Research Center College of Medicine National Cheng Kung University Zhunan Miaoli County Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I Hui","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Department of Psychiatry National Cheng Kung University Hospital Tainan Taiwan"},{"name":"Center for Neuropsychiatric Research National Health Research Institute Zhunan Miaoli County Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kao Chin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Department of Psychiatry National Cheng Kung University Hospital Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"San\u2010Yuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Tri\u2010Service General Hospital National Defense Medical Center Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen Kuang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Department of Psychiatry National Cheng Kung University Hospital Tainan Taiwan"},{"name":"Addiction Research Center College of Medicine National Cheng Kung University Zhunan Miaoli County Taiwan"},{"name":"Institute of Behavioral Medicine College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Chen","family":"Ko","sequence":"additional","affiliation":[{"name":"Division of Clinical Psychology Institute of Allied Health Sciences Tainan Taiwan"},{"name":"Department of Psychology Asia University Taichung Taiwan"},{"name":"Institute of Behavioral Medicine College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru\u2010Band","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Clinical Psychology Institute of Allied Health Sciences Tainan Taiwan"},{"name":"Department of Psychiatry College of Medicine National Cheng Kung University Tainan 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