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However, little is known about the similarities and differences in interhemispheric functional connectivity between <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">UD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with bipolar <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> disorder (n\u00a0=\u00a036) and <jats:styled-content style=\"fixed-case\">UD<\/jats:styled-content> (n\u00a0=\u00a032) during a depressive episode as well as 40 healthy controls underwent resting\u2010state functional magnetic resonance imaging. The functional connectivity between any pair of symmetric interhemispheric voxels (i.e., functional homotopy) was measured by voxel\u2010mirrored homotopic connectivity (<jats:styled-content style=\"fixed-case\">VMHC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The three groups showed significant <jats:styled-content style=\"fixed-case\">VMHC<\/jats:styled-content> differences in the posterior cingulate cortex (<jats:styled-content style=\"fixed-case\">PCC<\/jats:styled-content>), fusiform and lingual gyrus, anterior lobe of the cerebellum (Ce<jats:styled-content style=\"fixed-case\">AL<\/jats:styled-content>), and posterior lobe of the cerebellum (Ce<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content>). In the <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> group, the <jats:styled-content style=\"fixed-case\">VMHC<\/jats:styled-content> decreases in the fusiform\/lingual gyrus, Ce<jats:styled-content style=\"fixed-case\">AL<\/jats:styled-content>, and Ce<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> were shown relative to controls. In the <jats:styled-content style=\"fixed-case\">UD<\/jats:styled-content> group, the <jats:styled-content style=\"fixed-case\">VMHC<\/jats:styled-content> decreases in the <jats:styled-content style=\"fixed-case\">PCC<\/jats:styled-content>, fusiform\/lingual gyrus, and Ce<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> were shown relative to controls. No regions of increased <jats:styled-content style=\"fixed-case\">VMHC<\/jats:styled-content> were detected in either patient group. There was no significant difference in the <jats:styled-content style=\"fixed-case\">VMHC<\/jats:styled-content> values in any brain region between the <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> group and the <jats:styled-content style=\"fixed-case\">UD<\/jats:styled-content> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Depressive episodes in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">UD<\/jats:styled-content> have similar impairments of interhemispheric coordination, which might imply an overlap in the neuropathology of depression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12315","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T04:46:01Z","timestamp":1433997961000},"page":"486-495","source":"Crossref","is-referenced-by-count":104,"title":["Interhemispheric resting state functional connectivity abnormalities in 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