{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T09:35:30Z","timestamp":1771925730873,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T00:00:00Z","timestamp":1441238400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2010\u20103631"],"award-info":[{"award-number":["2010\u20103631"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2011\u20104807"],"award-info":[{"award-number":["2011\u20104807"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholm County Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Brain\u2010derived neurotrophic factor (<jats:italic><jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content><\/jats:italic>) Val66Met (rs6265) functional polymorphism has been implicated in early\u2010onset bipolar disorder. However, results of studies are inconsistent. We aimed to further explore this association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> samples from the Treatment of Early Age Mania (<jats:styled-content style=\"fixed-case\">TEAM<\/jats:styled-content>) and Mayo Clinic Bipolar Disorder Biobank were investigated for association of rs6265 with early\u2010onset bipolar disorder. Bipolar cases were classified as <jats:italic>early onset<\/jats:italic> if the first manic or depressive episode occurred at age \u226419\u00a0years (versus adult\u2010onset cases at age &gt;19\u00a0years). After quality control, 69 <jats:styled-content style=\"fixed-case\">TEAM<\/jats:styled-content> early\u2010onset bipolar disorder cases, 725 Mayo Clinic bipolar disorder cases (including 189 early\u2010onset cases), and 764 controls were included in the analysis of association, assessed with logistic regression assuming log\u2010additive allele effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparison of <jats:styled-content style=\"fixed-case\">TEAM<\/jats:styled-content> cases with controls suggested association of early\u2010onset bipolar disorder with the rs6265 minor allele [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>)\u00a0=\u00a01.55, p\u00a0=\u00a00.04]. Although comparison of early\u2010onset adult bipolar disorder cases from the Mayo Clinic versus controls was not statistically significant, the <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> estimate indicated the same direction of effect (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.21, p\u00a0=\u00a00.19). When the early\u2010onset <jats:styled-content style=\"fixed-case\">TEAM<\/jats:styled-content> and Mayo Clinic early\u2010onset adult groups were combined and compared with the control group, the association of the minor allele rs6265 was statistically significant (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.30, p\u00a0=\u00a00.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These preliminary analyses of a relatively small sample with early\u2010onset bipolar disorder are suggestive that functional variation in <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> is implicated in bipolar disorder risk and may have a more significant role in early\u2010onset expression of the disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12323","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T15:37:12Z","timestamp":1441381032000},"page":"645-652","source":"Crossref","is-referenced-by-count":18,"title":["Association of brain\u2010derived neurotrophic factor (<i><scp>BDNF<\/scp><\/i>) Val66Met polymorphism with early\u2010onset bipolar disorder"],"prefix":"10.1111","volume":"17","author":[{"given":"Malik","family":"Nassan","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul E","family":"Croarkin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan L","family":"Luby","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marin","family":"Veldic","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paramjit T","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Children's National Medical Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan L","family":"McElroy","sequence":"additional","affiliation":[{"name":"Linder Center of HOPE Mason OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M","family":"Post","sequence":"additional","affiliation":[{"name":"Bipolar Collaborative Network Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T","family":"Walkup","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Weil Cornell Medical College New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Cercy","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer R","family":"Geske","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen D","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of Texas Medical Branch Galveston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo B","family":"Cuellar\u2010Barboza","sequence":"additional","affiliation":[{"name":"Universidad Autonoma de Nuevo Leon Neuvo Leon Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah","family":"Casuto","sequence":"additional","affiliation":[{"name":"Linder Center of HOPE Mason OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catharina","family":"Lavebratt","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden"},{"name":"Center for Molecular Medicine Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Schalling","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden"},{"name":"Center for Molecular Medicine Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter S","family":"Jensen","sequence":"additional","affiliation":[{"name":"The REACH Institute New York NY 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