{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:36:29Z","timestamp":1787531789977,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,8,20]],"date-time":"2015-08-20T00:00:00Z","timestamp":1440028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Tehran University of Medical Sciences","award":["22216"],"award-info":[{"award-number":["22216"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Recent research has focused on the inflammatory cascade as a key culprit in the etiology of bipolar disorder. We hypothesized that celecoxib, via its anti\u2010inflammatory properties, may have a therapeutic role in mood disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010six inpatients with the diagnosis of acute bipolar mania without psychotic features participated in a parallel, randomized, double\u2010blind, placebo\u2010controlled trial, and underwent six weeks of treatment with either celecoxib (400\u00a0mg daily) or placebo as an adjunctive treatment to sodium valproate. Patients were evaluated using the Young Mania Rating Scale (YMRS) and Hamilton Depression Rating Scale (HDRS). The primary outcome measure with respect to efficacy was the mean decrease in YMRS score from baseline to the study endpoint, which was compared between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant difference was observed in the change in YMRS scores on Day 42 compared to baseline in the two groups (p\u00a0&lt;\u00a00.001). The changes at the endpoint compared to baseline were \u221229.78\u00a0\u00b1\u00a021.78 (mean\u00a0\u00b1\u00a0standard deviation) and \u221221.78\u00a0\u00b1\u00a07.16 for the celecoxib and placebo groups, respectively. A significantly higher remission rate was observed in the celecoxib group (87.0%) than the placebo group (43.5%) at Week 6 (p\u00a0=\u00a00.005). General linear model repeated measures demonstrated a significant effect for the time\u00a0\u00d7\u00a0treatment interaction on the YMRS scores [\n                      <jats:italic>F<\/jats:italic>\n                      (2.27,99.98)\u00a0=\u00a06.67, p\u00a0=\u00a00.001].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Celecoxib is an effective adjuvant therapy in the treatment of manic episodes (without psychotic features) of bipolar mood disorder. The mood\u2010stabilizing role of the drug might be mediated via its action on the inflammatory cascade.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.12324","type":"journal-article","created":{"date-parts":[[2015,8,20]],"date-time":"2015-08-20T09:04:40Z","timestamp":1440061480000},"page":"606-614","source":"Crossref","is-referenced-by-count":88,"title":["Celecoxib adjunctive therapy for acute bipolar\u00a0mania: a randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"17","author":[{"given":"Somayeh","family":"Arabzadeh","sequence":"first","affiliation":[{"name":"Psychiatric Research Center Roozbeh Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niusha","family":"Ameli","sequence":"additional","affiliation":[{"name":"Qods Hospital Kurdistan University of Medical Sciences Sanandaj 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