{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T21:07:25Z","timestamp":1773436045071,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T00:00:00Z","timestamp":1441238400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Consejo Nacional de Ciencia y Tecnolog\u00eda (CONACYT)","award":["I0013-APOY-COMPL-2008"],"award-info":[{"award-number":["I0013-APOY-COMPL-2008"]}]},{"name":"Consejo Nacional de Ciencia y Tecnolog\u00eda (CONACYT)","award":["91270"],"award-info":[{"award-number":["91270"]}]},{"DOI":"10.13039\/501100009347","name":"Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009347","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The prevalence of obesity has dramatically increased in many countries and it is particularly high in patients with bipolar disorder (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>). A region in the first intron of the fat mass\u2010 and obesity\u2010associated (<jats:styled-content style=\"fixed-case\">FTO<\/jats:styled-content>) gene, encompassing markers rs9939973, rs8050136, and rs9939609, has been consistently associated with obesity and body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) in different populations. We sought to determine whether <jats:styled-content style=\"fixed-case\">FTO<\/jats:styled-content> is associated with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and\/or obesity in patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The sample included 129 Mexican Mestizo patients with bipolar I or bipolar <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> disorder. After obtaining informed consent, participants were evaluated with the Structured Clinical Interview for <jats:styled-content style=\"fixed-case\">DSM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> Axis I Disorders and weight, height, and body measurements were recorded. <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was extracted from a 5\u2010<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> blood sample and real\u2010time polymerase chain reaction was performed. The results were analyzed with Haploview v4.2 and <jats:styled-content style=\"fixed-case\">SPSS<\/jats:styled-content> v21.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Differences in mean <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> were explained by rs8050136 and rs9939609 genotypes, especially by comparing non\u2010carriers and carriers of two copies of the risk allele (Tukey's p\u00a0\u2264\u00a00.019), with a mean difference in <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> as high as 7.81\u00a0kg\/m<jats:sup>2<\/jats:sup>. Differences in <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> were also explained by the interaction of the genotype (rs8050136 and\/or rs9939609), the use of second\u2010generation antipsychotics, and the use of mood stabilizers (p\u00a0\u2264\u00a00.41). Obesity was also associated with these two markers when patients with and without obesity were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>, differences in <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> may be affected by the presence of <jats:styled-content style=\"fixed-case\">FTO<\/jats:styled-content> risk alleles, especially in homozygous individuals for these variants. Besides evaluating the possible metabolic effects of certain antipsychotics or mood stabilizers, it is important to evaluate the role of other factors such as <jats:styled-content style=\"fixed-case\">FTO<\/jats:styled-content> risk alleles.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12328","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T15:37:12Z","timestamp":1441381032000},"page":"662-669","source":"Crossref","is-referenced-by-count":7,"title":["Differences in body mass index according to fat mass\u2010 and obesity\u2010associated (<scp>FTO<\/scp>) genotype in Mexican patients with bipolar disorder"],"prefix":"10.1111","volume":"17","author":[{"given":"Adriana","family":"D\u00edaz\u2010Anzald\u00faa","sequence":"first","affiliation":[{"name":"Departamento de Gen\u00e9tica Subdirecci\u00f3n de Investigaciones Cl\u00ednicas Instituto Nacional de Pisquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz (INPRF) Mexico D.F Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Ocampo\u2010Mendoza","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica Subdirecci\u00f3n de Investigaciones Cl\u00ednicas Instituto Nacional de Pisquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz (INPRF) Mexico D.F Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Octavio","family":"Hern\u00e1ndez\u2010Lagunas","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica Subdirecci\u00f3n de Investigaciones Cl\u00ednicas Instituto Nacional de Pisquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz (INPRF) Mexico D.F Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico Alejandro","family":"D\u00edaz\u2010Madrid","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica Subdirecci\u00f3n de Investigaciones Cl\u00ednicas Instituto Nacional de Pisquiatr\u00eda Ram\u00f3n de la 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