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However, questions still exist regarding the exact profile of these deficits in terms of the domains most affected, their origins, and their relationship to clinical subtypes. This review aims to examine the current state of the evidence and to examine ways in which the field may be advanced.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Studies examining cognitive function in bipolar disorder (\n                      <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>\n                      ) and unipolar major depression (\n                      <jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content>\n                      ) were examined. Given the number and variability of such studies, particular attention was paid to meta\u2010analyses and to meta\u2010regression analyses which examined the possible mediators of cognitive impairment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Meta\u2010analyses are available for\n                      <jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>\n                      in both depression and euthymia. Several analyses examine mediators. Results do not support the presence of domain specific deficits but rather a moderate deficit across a range of domains in\n                      <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>\n                      and in\n                      <jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content>\n                      . The data on clinical mediators is inconsistent, even with regard to the effect of mood state.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A two\u2010tiered approach, with the broad\u2010based application of standardized measures on a large\u2010scale, and the refined application of theoretically driven experimental development would significantly further our understanding of neurocognitive processing in mood disorder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.12342","type":"journal-article","created":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T01:07:07Z","timestamp":1450660027000},"page":"21-40","source":"Crossref","is-referenced-by-count":113,"title":["The neurocognitive profile of mood disorders \u2013 a review of the evidence and methodological issues"],"prefix":"10.1111","volume":"17","author":[{"given":"Richard 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