{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:05:43Z","timestamp":1775001943685,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T00:00:00Z","timestamp":1455494400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["09\/52825\u20108"],"award-info":[{"award-number":["09\/52825\u20108"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2016,2]]},"abstract":"Objectives<\/jats:title>Cognitive impairment is a common feature of late\u2010life bipolar disorder (BD<\/jats:styled-content>). Yet, there is limited information on the biological mechanisms associated with this process. It is uncertain whether cognitively impaired patients with BD<\/jats:styled-content> may present the Alzheimer's disease (AD<\/jats:styled-content>) bio\u2010signature<\/jats:italic> in the cerebrospinal fluid (CSF<\/jats:styled-content>), defined as a combination of low concentrations of the amyloid\u2010beta peptide (A\u03b21\u201042<\/jats:sub>) and high concentrations of total tau (T\u2010tau) and tau phosphorylated at threonine 181 (P\u2010tau). In this study, we sought to determine whether cognitive impairment in elderly patients with BD<\/jats:styled-content> is associated with the AD CSF<\/jats:styled-content> bio\u2010signature.<\/jats:p><\/jats:sec>Methods<\/jats:title>Seventy\u2010two participants were enrolled in the study. The test group comprised older adults with BD<\/jats:styled-content> and mild cognitive impairment (BD<\/jats:styled-content>\u2010MCI<\/jats:styled-content>; n\u00a0=\u00a016) and the comparison groups comprised patients with dementia due to AD<\/jats:styled-content> (n\u00a0=\u00a017), patients with amnestic MCI (aMCI<\/jats:styled-content>; n\u00a0=\u00a014), and cognitively healthy older adults (control group; n\u00a0=\u00a025). CSF<\/jats:styled-content> samples were obtained by lumbar puncture and concentrations of A\u03b21\u201042<\/jats:sub>, T\u2010tau and P\u2010tau were determined.<\/jats:p><\/jats:sec>Results<\/jats:title>CSF<\/jats:styled-content> concentrations of all biomarkers were significantly different in the AD<\/jats:styled-content> group compared to all other groups, but did not differentiate BD<\/jats:styled-content>\u2010MCI<\/jats:styled-content> subjects from aMCI<\/jats:styled-content> subjects and controls. BD<\/jats:styled-content>\u2010MCI<\/jats:styled-content> patients had a non\u2010significant reduction in CSF<\/jats:styled-content> A\u03b21\u201042<\/jats:sub> compared to controls, but this was still higher than in the AD<\/jats:styled-content> group. Concentrations of T\u2010tau and P\u2010tau in BD<\/jats:styled-content>\u2010MCI<\/jats:styled-content> patients were similar to those in controls, and significantly lower than those in AD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Cognitively impaired patients with BD<\/jats:styled-content> do not display the so\u2010called AD<\/jats:styled-content> bio\u2010signature<\/jats:italic> in the CSF<\/jats:styled-content>. We therefore hypothesize that cognitive deterioration in BD<\/jats:styled-content> is not associated with the classical pathophysiological mechanisms observed in AD<\/jats:styled-content>, i.e., amyloid deposition and hyperphosphorylation of microtubule\u2010associated tau protein.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12360","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T12:46:52Z","timestamp":1455540412000},"page":"63-70","source":"Crossref","is-referenced-by-count":38,"title":["Cognitive impairment in late\u2010life bipolar disorder is not associated with Alzheimer's disease pathological signature in the cerebrospinal fluid"],"prefix":"10.1111","volume":"18","author":[{"given":"Orestes V","family":"Forlenza","sequence":"first","affiliation":[{"name":"Laboratory of Neuroscience (LIM\u201027) Department and Institute of Psychiatry Faculty of Medicine University of S\u00e3o 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