{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:19:29Z","timestamp":1791195569258,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T00:00:00Z","timestamp":1455580800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate whether there is an increased risk of cancer associated with lithium treatment in patients with bipolar disorder compared to the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A nationwide Swedish register study of incidence rate ratios (<jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content>s) of total cancer and site\u2010specific cancer in the 50\u201384\u2010year age range was carried out in patients with bipolar disorder (n\u00a0=\u00a05,442) with and without lithium treatment from July 2005 to December 2009 compared to the general population using linked information from The Swedish Cancer Register, The National Patient Register, and The Drug Prescription Register.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall cancer risk was not increased in patients with bipolar disorder. There was no difference in risk of unspecified cancer, neither in patients with lithium treatment compared to the general population [<jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content>\u00a0=\u00a01.04, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 0.89\u20131.23] nor in patients with bipolar disorder without lithium treatment compared to the general population (<jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content>\u00a0=\u00a01.03, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.89\u20131.19). The cancer risk was significantly increased in patients with bipolar disorder without lithium treatment in the digestive organs (<jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content>\u00a0=\u00a01.47, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.12\u20131.93), in the respiratory system and intrathoracic organs (<jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content>\u00a0=\u00a01.72, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.11\u20132.66), and in the endocrine glands and related structures (<jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content>\u00a0=\u00a02.60, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.24\u20135.47), but in patients with bipolar disorder with lithium treatment, there was no significantly increased cancer risk compared to the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bipolar disorder was not associated with increased cancer incidence and neither was lithium treatment in these patients. Specifically, there was an increased risk of respiratory, gastrointestinal, and endocrine cancer in patients with bipolar disorder <jats:italic>without<\/jats:italic> lithium treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12361","type":"journal-article","created":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T14:59:59Z","timestamp":1455634799000},"page":"33-40","source":"Crossref","is-referenced-by-count":55,"title":["Lithium treatment and cancer incidence in bipolar disorder"],"prefix":"10.1111","volume":"18","author":[{"given":"Lina","family":"Martinsson","sequence":"first","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden"},{"name":"Centre for Psychiatric Research and Education Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"Westman","sequence":"additional","affiliation":[{"name":"Division for Family Medicine Department of Neurobiology, Care Sciences and Society Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"H\u00e4llgren","sequence":"additional","affiliation":[{"name":"Division for Family Medicine Department of Neurobiology, Care Sciences and Society Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urban","family":"\u00d6sby","sequence":"additional","affiliation":[{"name":"Division for Family Medicine Department of Neurobiology, Care Sciences and Society Karolinska Institutet Stockholm Sweden"},{"name":"Center for Molecular Medicine Karolinska University Hospital Solna Stockholm Sweden"},{"name":"Department of Adult Psychiatry PRIMA Barn och Vuxenpsykiatri AB Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Backlund","sequence":"additional","affiliation":[{"name":"Centre for Psychiatric Research and Education Stockholm Sweden"},{"name":"Neurogenetics Unit Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2010.00878.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00502.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e32834de3de"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.9.844"},{"key":"e_1_2_8_6_1","volume-title":"Manic\u2010Depressive Illness; Bipolar Disorders and Recurrent Depression","author":"Goodwin FK","year":"2007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb05796.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200317070-00003"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.111.005512"},{"key":"e_1_2_8_10_1","first-page":"461","article-title":"Neuroprotective action of lithium in disorders of the central nervous system","volume":"36","author":"Chiu CT","year":"2011","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00144.2011"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs538"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.889398"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12344"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015010061"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/2194-7511-2-6"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.178"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-002373"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067133"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12293"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-004295"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674371005501203"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1359786810385489"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbr162"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860802247664"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-450"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2011.01747.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.05.015"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181c17da8"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2000.101005382.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.09.003"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.06.010"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284692"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2015.13.1.1"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.3982"},{"key":"e_1_2_8_37_1","first-page":"352","article-title":"Lithium increases radiosensitivity by abrogating DNA repair in breast cancer spheroid culture","volume":"17","author":"Rouhani M","year":"2014","journal-title":"Arch Iran Med"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21300"},{"key":"e_1_2_8_39_1","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1097\/CAD.0b013e32834ac8fc","article-title":"Glycogen synthase kinase 3beta inhibitors induce apoptosis in ovarian cancer cells and inhibit in\u2010vivo tumor growth","volume":"22","author":"Hilliard TS","year":"2011","journal-title":"Anticancer Drugs"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.37"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyv002"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2015.06.016"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.368282"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11269"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140816617"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbdi.12361","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bdi.12361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T14:28:33Z","timestamp":1695565713000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bdi.12361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/bdi.12361"],"URL":"https:\/\/doi.org\/10.1111\/bdi.12361","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2]]}}}