{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T11:51:39Z","timestamp":1773057099717,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T00:00:00Z","timestamp":1455494400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["466625\/2014\u20106"],"award-info":[{"award-number":["466625\/2014\u20106"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2016,2]]},"abstract":"Objectives<\/jats:title>Cognitive decline is part of the long\u2010term outcome for many individuals with bipolar disorder (BD<\/jats:styled-content>). The \u03b54 allele (APOE<\/jats:styled-content>*4<\/jats:italic>) of apolipoprotein E (APOE<\/jats:styled-content><\/jats:italic>) is a well\u2010established risk factor for dementia in Alzheimer's disease (AD<\/jats:styled-content>). However, its contribution to the risk of cognitive deterioration in BD<\/jats:styled-content> has not yet been determined. Our aim was to analyze the APOE<\/jats:styled-content><\/jats:italic> genotype association with cognitive status in a sample of older adults with BD<\/jats:styled-content> and compare this to the association in individuals with AD<\/jats:styled-content>, individuals with mild cognitive impairment (MCI<\/jats:styled-content>), and healthy controls.<\/jats:p><\/jats:sec>Methods<\/jats:title>Participants (n\u00a0=\u00a0475) were allocated to four groups: individuals with BD<\/jats:styled-content> (n\u00a0=\u00a077), those with AD<\/jats:styled-content> (n\u00a0=\u00a0211), those with MCI<\/jats:styled-content> (n\u00a0=\u00a043), and healthy controls (n\u00a0=\u00a0144) according to clinical and neuropsychological assessment. APOE<\/jats:styled-content><\/jats:italic> was genotyped by real\u2010time polymerase chain reaction. Tukey's honest significant difference test and Pearson's chi\u2010squared test were used to compare diagnostic groups.<\/jats:p><\/jats:sec>Results<\/jats:title>Subjects with BD<\/jats:styled-content> were similar to controls with respect to the distribution of the APOE<\/jats:styled-content><\/jats:italic> genotype (p\u00a0=\u00a00.636) and allele frequencies (p\u00a0=\u00a00.481). Significant differences were found when comparing the AD<\/jats:styled-content> group to the BD<\/jats:styled-content> group or to controls (APOE<\/jats:styled-content><\/jats:italic> genotype: p\u00a0<\u00a00.0002; allele frequencies: p\u00a0<\u00a00.001). APOE<\/jats:styled-content>*4<\/jats:italic> was significantly increased in the AD<\/jats:styled-content> group when compared to the BD<\/jats:styled-content> group (p\u00a0=\u00a00.031) and controls (p\u00a0<\u00a00.0001). The cognitively impaired BD<\/jats:styled-content> subgroup (Mini\u2010Mental State Examination below the cutoff score and\/or neuropsychological assessment compatible with MCI<\/jats:styled-content>) had a statistically significant higher frequency of APOE<\/jats:styled-content>*2<\/jats:italic> compared to the AD<\/jats:styled-content> group (p\u00a0=\u00a00.003).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>APOE<\/jats:styled-content>*4<\/jats:italic> is not associated with the diagnosis of BD<\/jats:styled-content> and does not impact the occurrence of dementia in BD<\/jats:styled-content>. Given the distinct clinical and biological features of cognitive impairment in BD<\/jats:styled-content>, we hypothesized that dementia in BD<\/jats:styled-content> is unrelated to AD<\/jats:styled-content> pathological mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12367","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T12:44:36Z","timestamp":1455540276000},"page":"71-77","source":"Crossref","is-referenced-by-count":11,"title":["Apolipoprotein E genotype is not associated with cognitive impairment in older adults with bipolar disorder"],"prefix":"10.1111","volume":"18","author":[{"given":"Daniel Shikanai","family":"Kerr","sequence":"first","affiliation":[{"name":"Laboratory of Neuroscience (LIM\u201027) Department and Institute of Psychiatry Faculty of Medicine University of S\u00e3o Paulo (USP) S\u00e3o Paulo SP Brazil"},{"name":"Center for Interdisciplinary Research on Applied Neurosciences (NAPNA) University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florindo","family":"Stella","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroscience (LIM\u201027) Department and Institute of Psychiatry Faculty of Medicine University of S\u00e3o Paulo (USP) S\u00e3o Paulo SP Brazil"},{"name":"Biosciences Institute UNESP\u2013Universidade Estadual Paulista S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia","family":"Radanovic","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroscience (LIM\u201027) Department and Institute of Psychiatry Faculty of Medicine University of S\u00e3o Paulo (USP) S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Aprahamian","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroscience (LIM\u201027) Department and Institute of Psychiatry Faculty of Medicine University of S\u00e3o Paulo (USP) S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Henrique Ferreira","family":"Bertollucci","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery Federal University of S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orestes Vicente","family":"Forlenza","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroscience (LIM\u201027) Department and Institute of Psychiatry Faculty of Medicine University of S\u00e3o Paulo (USP) S\u00e3o Paulo SP Brazil"},{"name":"Center for Interdisciplinary Research on Applied Neurosciences (NAPNA) University of S\u00e3o Paulo S\u00e3o Paulo SP 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