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The current study investigated neurocognitive functioning in first\u2010treatment (<jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>\u2010I compared to <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content> schizophrenia (<jats:styled-content style=\"fixed-case\">SCZ<\/jats:styled-content>), and healthy controls (<jats:styled-content style=\"fixed-case\">HCs<\/jats:styled-content>), and the effect of history of psychosis and previous episodes in the two clinical groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 202 <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>\u2010I (n = 101) and <jats:styled-content style=\"fixed-case\">SCZ<\/jats:styled-content> spectrum disorder (n = 101), in addition to <jats:styled-content style=\"fixed-case\">HCs<\/jats:styled-content> (n = 101), were included. A comprehensive neurocognitive test battery was used to assess verbal learning and memory, executive functioning, processing speed, and attention and working memory. Neurocognitive functioning and the effect of history of psychosis and number of previous episodes were analyzed using separate multivariate analyses of variance and correlation analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>\u2010I performed intermediately between <jats:styled-content style=\"fixed-case\">FT SCZ<\/jats:styled-content> spectrum patients and <jats:styled-content style=\"fixed-case\">HCs<\/jats:styled-content> on all measures. Compared to <jats:styled-content style=\"fixed-case\">HCs<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FT BD<\/jats:styled-content>\u2010I showed impaired functioning across all neurocognitive domains. No differences in neurocognitive functioning were observed in psychotic versus nonpsychotic <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>\u2010I. With the exception of an association between number of manic episodes and two measures of executive function in <jats:styled-content style=\"fixed-case\">FT BD<\/jats:styled-content>\u2010I, no associations were found between number of episodes and neurocognitive performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neurocognitive impairments were present in <jats:styled-content style=\"fixed-case\">FT BD<\/jats:styled-content>\u2010I, and were not explained by history of psychosis or number of previous psychotic or depressive episodes. There were indications that executive function could be associated with number of previous manic episodes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12377","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T07:13:34Z","timestamp":1458371614000},"page":"136-147","source":"Crossref","is-referenced-by-count":21,"title":["History of psychosis and previous episodes as potential explanatory factors for neurocognitive impairment in first\u2010treatment bipolar I disorder"],"prefix":"10.1111","volume":"18","author":[{"given":"Christine","family":"Demmo","sequence":"first","affiliation":[{"name":"NORMENT KG Jebsen Centre for Psychosis Research Oslo University Hospital and Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine Vik","family":"Lagerberg","sequence":"additional","affiliation":[{"name":"NORMENT KG Jebsen Centre for Psychosis Research Oslo University Hospital and 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