{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:07Z","timestamp":1787013907147,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,7,9]],"date-time":"2016-07-09T00:00:00Z","timestamp":1468022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["039\u20104654"],"award-info":[{"award-number":["039\u20104654"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2016,8]]},"abstract":"\n Objectives<\/jats:title>\n \n Bipolar disorder (\n BD<\/jats:styled-content>\n ) is a complex psychiatric\u00a0disorder\u00a0characterized by mania and depression. Alterations in brain Na\n +<\/jats:sup>\n , K\n +<\/jats:sup>\n \u2010\n ATP<\/jats:styled-content>\n ase and cardiac steroids (\n CSs<\/jats:styled-content>\n ) have been detected in\n BD<\/jats:styled-content>\n , raising the hypothesis of their involvement in this pathology. The present study investigated the behavioral and biochemical consequences of a reduction in endogenous brain\n CS<\/jats:styled-content>\n activity in animal models of mania.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Amphetamine (\n AMPH<\/jats:styled-content>\n )\u2010induced hyperactivity in\n BALB<\/jats:styled-content>\n \/c and black Swiss mice served as a model of mania. Behavior was evaluated in the open\u2010field test in na\u00efve mice or in mice treated with anti\u2010ouabain antibodies.\n CS<\/jats:styled-content>\n levels were determined by enzyme\u2010linked immunosorbent assay (\n ELISA)<\/jats:styled-content>\n , using sensitive and specific anti\u2010ouabain antibodies. Extracellular signal\u2010regulated kinase (ERK) and protein kinase B (Akt) phosphorylation levels in the frontal cortex were determined by western blot analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Administration of\n AMPH<\/jats:styled-content>\n to\n BALB<\/jats:styled-content>\n \/c and black Swiss mice resulted in a marked increase in locomotor activity, accompanied by a threefold increase in brain\n CSs<\/jats:styled-content>\n . The lowering of brain\n CSs<\/jats:styled-content>\n by the administration of anti\u2010ouabain antibodies prevented the hyperactivity and the increase in brain\n CS<\/jats:styled-content>\n levels.\n AMPH<\/jats:styled-content>\n caused an increase in phosphorylated ERK (p\u2010ERK) and phosphorylated Akt (p\u2010Akt) levels in the frontal cortex, which was significantly reduced by administration of the antibodies. A synthetic \u2018functional antagonist\u2019 of\n CS<\/jats:styled-content>\n s, 4\u2010(3\u2032\u03b1\u201015\u2032\u03b2\u2010dihydroxy\u20105\u2032\u03b2\u2010estran\u201017\u2032\u03b2\u2010yl) furan\u20102\u2010methyl alcohol, also resulted in attenuation of\n AMPH<\/jats:styled-content>\n \u2010induced hyperactivity.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n These results are in accordance with the notion that malfunctioning of the Na\n +<\/jats:sup>\n , K\n +<\/jats:sup>\n \u2010\n ATP<\/jats:styled-content>\n ase\/\n CS<\/jats:styled-content>\n system may be involved in the manifestation of mania and identify this system as a potential new target for drug development.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bdi.12413","type":"journal-article","created":{"date-parts":[[2016,7,9]],"date-time":"2016-07-09T03:17:07Z","timestamp":1468034227000},"page":"451-459","source":"Crossref","is-referenced-by-count":26,"title":["Endogenous cardiac steroids in animal models of mania"],"prefix":"10.1111","volume":"18","author":[{"given":"Anastasia","family":"Hodes","sequence":"first","affiliation":[{"name":"Department of Medical Neurobiology Institute for Medical Research Israel\u2010Canada The Hebrew University\u2010Hadassah Medical School Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haim","family":"Rosen","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Molecular Genetics Institute for Medical Research Israel\u2010Canada The Hebrew University\u2010Hadassah Medical School Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Deutsch","sequence":"additional","affiliation":[{"name":"Institute for Drug Research School of Pharmacy The Hebrew University Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzuri","family":"Lifschytz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hadassah Hospital Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haim","family":"Einat","sequence":"additional","affiliation":[{"name":"School of Behavioral Sciences Tel Aviv\u2010Yaffo Academic College Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lichtstein","sequence":"additional","affiliation":[{"name":"Department of Medical Neurobiology Institute for Medical Research Israel\u2010Canada The Hebrew University\u2010Hadassah Medical School Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.12"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e8508"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867412449303"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00707.2004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.14.6259"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)80898-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.03.013"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00098.2007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2741\/1694"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.71.102201.141218"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1124\/mi.3.3.157"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/00129784-200707030-00004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)00201-D"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1515\/JBCPP.2000.11.4.375"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00343-0"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.10.033"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1108416108"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6394(1997)5:2<53::AID-DA1>3.0.CO;2-6"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2009.03.032"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.12.021"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2011.05.007"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2003.00053.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2010.00827.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(98)00186-6"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00336.2011"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00428028"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(00)00318-1"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2016.02.038"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-015-4098-4"},{"key":"e_1_2_6_31_1","first-page":"37","article-title":"Frequency of stimulant treatment and of stimulant\u2010associated mania\/hypomania in bipolar disorder patients","volume":"41","author":"Wingo AP","year":"2008","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.11.006"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00760.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00734.2009"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.04.047"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2014.03.013"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.04.010"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.05.027"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3283623725"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2014.02.002"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0505819"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2005.02.009"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5479.71"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.118.543.219"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(93)90089-9"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037604"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-009-0198-9"},{"key":"e_1_2_6_48_1","first-page":"10","article-title":"Strain\u2010specific battery of tests for domains of mania: effects of valproate, lithium and imipramine","volume":"1","author":"Flaisher\u2010Grinberg S","year":"2010","journal-title":"Front Psychiatry"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1159\/000381785"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.106"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.68052032.x"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04300.x"},{"key":"e_1_2_6_53_1","doi-asserted-by":"crossref","first-page":"6295","DOI":"10.1523\/JNEUROSCI.23-15-06295.2003","article-title":"Segregation of amphetamine reward and locomotor stimulation between nucleus accumbens medial shell and core","volume":"23","author":"Sellings LH","year":"2003","journal-title":"J Neurosci"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2011.08.011"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.5.H1899"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(85)90069-5"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00581.2009"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.02.005"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbdi.12413","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bdi.12413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T06:39:35Z","timestamp":1696228775000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bdi.12413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,9]]},"references-count":57,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/bdi.12413"],"URL":"https:\/\/doi.org\/10.1111\/bdi.12413","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,9]]}}}