{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:26:32Z","timestamp":1789986392973,"version":"4.0.1"},"reference-count":62,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T00:00:00Z","timestamp":1476835200000},"content-version":"vor","delay-in-days":48,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institutes of Mental Health","doi-asserted-by":"crossref","award":["RO1-MH0698567"],"award-info":[{"award-number":["RO1-MH0698567"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000025","name":"National Institutes of Mental Health","doi-asserted-by":"crossref","award":["RO1-MH060881"],"award-info":[{"award-number":["RO1-MH060881"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Center of Excellence in Neurosciences at the Paul L. Foster School of Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Objectives<\/jats:title>Recent genome\u2010wide association studies (GWAS<\/jats:styled-content>s) have identified numerous putative genetic polymorphisms associated with bipolar disorder (BD<\/jats:styled-content>) and\/or schizophrenia (SC<\/jats:styled-content>). We hypothesized that a portion of these polymorphisms would also be associated with BD<\/jats:styled-content> in the Latino American population. To identify such regions, we tested previously identified genetic variants associated with BD<\/jats:styled-content> and\/or SC<\/jats:styled-content> and ancestral haploblocks containing these single nucleotide polymorphisms (SNP<\/jats:styled-content>s) in a sample of Latino subjects with BD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 2254 Latino individuals were genotyped for 91 SNP<\/jats:styled-content>s identified in previous BD<\/jats:styled-content> and\/or SC GWAS<\/jats:styled-content>s, along with selected SNP<\/jats:styled-content>s in strong linkage disequilibrium with these markers. Family\u2010based single marker and haplotype association testing was performed using the PBAT<\/jats:styled-content> software package. Empirical P<\/jats:italic>\u2010values were derived from 10\u00a0000 permutations.<\/jats:p><\/jats:sec>Results<\/jats:title>Associations of eight a priori <\/jats:italic>GWAS SNP<\/jats:styled-content>s with BD<\/jats:styled-content> were replicated with nominal (P<\/jats:italic>\u2264.05) levels of significance. These included SNP<\/jats:styled-content>s within nuclear factor I A (NFIA<\/jats:styled-content><\/jats:italic>), serologically defined colon cancer antigen 8 (SDCCAG<\/jats:styled-content>8<\/jats:italic>), lysosomal associated membrane protein 3 (LAMP<\/jats:styled-content>3<\/jats:italic>), nuclear factor kappa B subunit 1 (NFKB<\/jats:styled-content>1<\/jats:italic>), major histocompatibility complex, class I, B (HLA<\/jats:styled-content>\u2010B<\/jats:italic>) and 5\u2032\u2010nucleotidase, cytosolic II (NT<\/jats:styled-content>5C2<\/jats:italic>) and SNP<\/jats:styled-content>s within intragenic regions microRNA 6828 (MIR<\/jats:styled-content>6828<\/jats:italic>)\u2014<\/jats:italic>solute carrier family 7 member 14 (SLC<\/jats:styled-content>7A14<\/jats:italic>) and sonic hedgehog (SHH<\/jats:styled-content><\/jats:italic>)\u2014<\/jats:italic>long intergenic non\u2010protein coding RNA 1006 (LINC<\/jats:styled-content>01006<\/jats:italic>). Of the 76 ancestral haploblocks that were tested for associations with BD<\/jats:styled-content>, our top associated haploblock was located in LAMP<\/jats:styled-content>3<\/jats:italic>; however, the association did not meet statistical thresholds of significance following Bonferroni correction.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>These results indicate that some of the gene variants found to be associated with BD<\/jats:styled-content> or SC<\/jats:styled-content> in other populations are also associated with BD<\/jats:styled-content> risk in Latinos. Variants in six genes and two intragenic regions were associated with BD<\/jats:styled-content> in our Latino sample and provide additional evidence for overlap in genetic risk between SC<\/jats:styled-content> and BD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12438","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T11:15:19Z","timestamp":1476875719000},"page":"520-527","source":"Crossref","is-referenced-by-count":30,"title":["Replication of genome\u2010wide association study (GWAS<\/scp>) susceptibility loci in a Latino bipolar disorder cohort"],"prefix":"10.1111","volume":"18","author":[{"given":"Suzanne","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Center of Excellence in Neurosciences Department of Biomedical Sciences Paul L. 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