{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:51:38Z","timestamp":1789469498167,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T00:00:00Z","timestamp":1493337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate feasibility and effects of a sub\u2010anesthetic infusion dose of ketamine versus midazolam on suicidal ideation in bipolar depression. Neurocognitive, blood and saliva biomarkers were explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen participants with bipolar depression and a Scale for Suicidal Ideation (<jats:styled-content style=\"fixed-case\">SSI<\/jats:styled-content>) score of \u22654 were randomized to ketamine (0.5\u00a0mg\/kg) or midazolam (0.02\u00a0mg\/kg). Current pharmacotherapy was maintained excluding benzodiazepines within 24\u00a0hours. The primary clinical outcome was <jats:styled-content style=\"fixed-case\">SSI<\/jats:styled-content> score on day 1 post\u2010infusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results supported feasibility. Mean reduction of <jats:styled-content style=\"fixed-case\">SSI<\/jats:styled-content> after ketamine infusion was almost 6 points greater than after midazolam, although this was not statistically significant (estimate=5.84, <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>=3.01, <jats:italic>t<\/jats:italic>=1.94, <jats:italic>P<\/jats:italic>=.074, 95% confidence interval (<jats:styled-content style=\"fixed-case\">[CI)]<\/jats:styled-content>=\u22120.65 to 12.31). The number needed to treat for response (<jats:styled-content style=\"fixed-case\">SSI<\/jats:styled-content> &lt;4 <jats:italic>and<\/jats:italic> at least 50% below baseline) was 2.2, and for remission (<jats:styled-content style=\"fixed-case\">SSI<\/jats:styled-content>=0) was 3.2. The strongest neurocognitive correlation was between memory improvement on the Selective Reminding Test (<jats:styled-content style=\"fixed-case\">SRT<\/jats:styled-content>) and reduction in <jats:styled-content style=\"fixed-case\">SSI<\/jats:styled-content> score on day 1 after ketamine (\u03c1=\u2212.89, <jats:italic>P<\/jats:italic>=.007). Pre\u2010 to post\u2010infusion decrease in serum brain derived neurotrophic factor (<jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content>) correlated with reduction in <jats:styled-content style=\"fixed-case\">SSI<\/jats:styled-content> from baseline to day 1 after ketamine (n=5, \u03c1=0.90, <jats:italic>P<\/jats:italic>=.037) but not midazolam (<jats:italic>P<\/jats:italic>=.087).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study demonstrated feasibility. Suicidal thoughts were lower after ketamine than after midazolam at a trend level of significance, likely due to the small pilot sample. Memory improvement and <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> are promising biomarkers. Replication is needed in an adequately powered full\u2010scale trial.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12487","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T11:34:53Z","timestamp":1493379293000},"page":"176-183","source":"Crossref","is-referenced-by-count":161,"title":["Ketamine versus midazolam in bipolar depression with suicidal thoughts: A pilot midazolam\u2010controlled randomized clinical trial"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5940-3478","authenticated-orcid":false,"given":"Michael F.","family":"Grunebaum","sequence":"first","affiliation":[{"name":"Molecular Imaging and Neuropathology Division Department of Psychiatry Columbia University Medical Center (CUMC) and New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Neuropathology Division Department of Psychiatry Columbia University Medical Center (CUMC) and New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Keilp","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Neuropathology Division Department of Psychiatry Columbia University Medical Center (CUMC) and New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek K.","family":"Moitra","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology CUMC  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas B.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Analytical Psychopharmacology Laboratory Nathan Kline Institute Research Foundation for Mental Hygiene of New York State  Orangeburg NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia E.","family":"Marver","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Neuropathology Division Department of Psychiatry Columbia University Medical Center (CUMC) and New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainsley K.","family":"Burke","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Neuropathology Division Department of Psychiatry Columbia University Medical Center (CUMC) and New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Milak","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Neuropathology Division Department of Psychiatry Columbia University Medical Center (CUMC) and New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Elizabeth","family":"Sublette","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Neuropathology Division Department of Psychiatry Columbia University Medical Center (CUMC) and New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Oquendo","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine at the University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. John","family":"Mann","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Neuropathology Division Department of Psychiatry Columbia University Medical Center (CUMC) and New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12271"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00467.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.12"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12087"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(14)70006-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa064135"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.05122032"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12098"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.11010163"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867415594427"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f3646"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.90"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.12.010"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.247"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.47.2.343"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.68.3.371"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13030392"},{"key":"e_1_2_8_21_1","volume-title":"Structured Clinical Interview for DSM\u2010IV Axis I Disorders (SCID)","author":"First MB","year":"1994"},{"key":"e_1_2_8_22_1","volume-title":"Structured Clinical Interview for DSM\u2010IV Axis II Personality Disorders (SCID\u2010II), (Version 2.0)","author":"First MB","year":"1996"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"e_1_2_8_24_1","volume-title":"Manual for the Profile of Mood States","author":"McNair DM","year":"1981"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"},{"key":"e_1_2_8_26_1","first-page":"218","volume-title":"ECDEU Assessment Manual for Psychopharmacology","author":"Guy WE","year":"1976"},{"key":"e_1_2_8_27_1","first-page":"343","article-title":"SAFTEE: a technique for the systematic assessment of side effects in clinical trials","volume":"22","author":"Levine J","year":"1986","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024465317902"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.2466\/pr0.1962.10.3.799"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2014.12.004"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.10.010"},{"key":"e_1_2_8_32_1","volume-title":"Exploratory Data Analysis","author":"Tukey JW","year":"1977"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.15040465"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291715001506"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2271"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0572-3"},{"key":"e_1_2_8_37_1","first-page":"298","article-title":"Ketamine impairs response inhibition and is positively reinforcing in healthy volunteers: a dose\u2010response study","volume":"172","author":"Morgan CJ","year":"2004","journal-title":"Psychopharmacology"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.298"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145714001011"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10130"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12436"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04659"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.54"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/00048670701213211"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(14)70639-X"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbdi.12487","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bdi.12487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T16:29:40Z","timestamp":1696350580000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bdi.12487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,28]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/bdi.12487"],"URL":"https:\/\/doi.org\/10.1111\/bdi.12487","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,28]]}}}