{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:30:10Z","timestamp":1783697410856,"version":"3.55.0"},"reference-count":75,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T00:00:00Z","timestamp":1493164800000},"content-version":"vor","delay-in-days":56,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000143","name":"Alzheimer Society","doi-asserted-by":"publisher","award":["13\u201032"],"award-info":[{"award-number":["13\u201032"]}],"id":[{"id":"10.13039\/501100000143","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["30801"],"award-info":[{"award-number":["30801"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We present a retrospective meta\u2010analysis of voxel\u2010based morphometry (<jats:styled-content style=\"fixed-case\">VBM<\/jats:styled-content>) of gray (<jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>) and white matter (<jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>) differences between patients with bipolar disorder (BD) and behaviorally healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used the activation likelihood estimation and Sleuth software for our meta\u2010analysis, considering <jats:italic>P<\/jats:italic>\u2010value maps at the cluster level inference of .05 with uncorrected <jats:italic>P<\/jats:italic>&lt;.001. Results were visualized with the software <jats:styled-content style=\"fixed-case\">MANGO<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included twenty\u2010five articles in the analysis, and separated the comparisons where <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> patients had <jats:italic>lower <\/jats:italic><jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content> concentrations than controls (573 subjects, 21 experiments, and 117 locations\/180 subjects, five experiments, and 15 locations, respectively) and the comparisons where <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> patients had <jats:italic>greater <\/jats:italic><jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> concentrations than controls (217 subjects, nine experiments, and 49 locations). Higher <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content> concentrations in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> patients were not detected. We observed for <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> reduced <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> concentrations in the left medial frontal gyrus and right inferior\/precentral gyri encompassing the insular cortex, and greater <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> concentrations in the left putamen. Further, lower <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content> concentrations were detected in the left inferior longitudinal fasciculus, left superior corona radiata, and left posterior cingulum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This meta\u2010analysis confirms deterioration of frontal and insular regions as already found in previous meta\u2010analysis. <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> reductions in these regions could be related to emotional processing and decision making, which are typically impaired in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>. Moreover, we found abnormalities in precentral frontal areas and putamen that have been linked to more basic functions, which could point to sensory and specific cognitive deficits. Finally, <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content> reductions involved circuitry that may contribute to emotional dysregulation in <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12488","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T11:37:33Z","timestamp":1493206653000},"page":"74-83","source":"Crossref","is-referenced-by-count":47,"title":["Voxel\u2010based morphometry meta\u2010analysis of gray and white matter finds significant areas of differences in bipolar patients from healthy controls"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6815-6787","authenticated-orcid":false,"given":"Rossana","family":"Ganzola","sequence":"first","affiliation":[{"name":"Institut universitaire en sant\u00e9 mentale de Qu\u00e9bec  Qu\u00e9bec City Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Duchesne","sequence":"additional","affiliation":[{"name":"Institut universitaire en sant\u00e9 mentale de Qu\u00e9bec  Qu\u00e9bec City Qu\u00e9bec Canada"},{"name":"D\u00e9partment de Radiologie Facult\u00e9 de M\u00e9decine Universit\u00e9 Laval  Qu\u00e9bec City Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60692-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.2.115"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(98)00142-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0111"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pra.0000320124.91799.2a"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.02.016"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0582"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2003.10.017"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2003.09.002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2008.02.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00414.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00666.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.03.077"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.03.022"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2011.11.002"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2011.05.005"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.52.1.59"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291711001450"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.01000.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.01.020"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2009.12.022"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2011.03.016"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1308.048"},{"key":"e_1_2_7_25_1","volume-title":"Co\u2010planar stereotaxic atlas of the human brain: 3\u2010dimensional proportional system: an approach to cerebral imaging","author":"Talairach J","year":"1988"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199403000-00005"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20136"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20718"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21186"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1385\/NI:3:1:065"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20345"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh274"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.02.026"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.07.020"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.186.5.369"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/00048670701213229"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.04.009"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-010-0183-1"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2011.00896.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.10.034"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881107082955"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.107.047498"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-014-1485-5"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.100140"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.11.030"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.1100"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.06.055"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12117"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12362"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001585"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1747"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002210000405"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2004.02.010"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20393"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(03)00090-4"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/2194-7511-1-3"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2012.02568.x"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)00910-0"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2004.00122.x"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(03)00116-2"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.8.781"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1087"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.04.027"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1399-5618.2003.00087.x"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2004.01.004"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.11.1841"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.yco.0000214339.06507.d8"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(02)00526-1"},{"key":"e_1_2_7_70_1","first-page":"627","article-title":"Frontal\u2010subcortical circuits and human behavior","volume":"44","author":"Cummings JL","year":"1998","journal-title":"J Psychosom Res"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.03.044"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.07.048"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2009.11.010"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.11030349"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.11.004"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbq026"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbdi.12488","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bdi.12488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T20:35:15Z","timestamp":1696365315000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bdi.12488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":75,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/bdi.12488"],"URL":"https:\/\/doi.org\/10.1111\/bdi.12488","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]}}}