{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T03:17:59Z","timestamp":1771039079799,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T00:00:00Z","timestamp":1498780800000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ANTIMANIC USE DURING PREGNANCY","award":["1R01MH07592101A1"],"award-info":[{"award-number":["1R01MH07592101A1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We conducted a prospective naturalistic study of pregnant women with bipolar disorder (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) to evaluate symptoms of <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> across childbearing and assess whether pharmacotherapy reduced their severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Assessments were scheduled at 20, 30, and 36\u00a0weeks' gestation and 2, 12, 26, and 52\u00a0weeks postpartum. Symptoms were assessed using the Structured Interview Guide for the Hamilton Depression Rating Scale\u2013Atypical Depression Supplement (<jats:styled-content style=\"fixed-case\">SIGH<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ADS<\/jats:styled-content>) and Mania Rating Scale (<jats:styled-content style=\"fixed-case\">MRS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pregnant women (N=152) with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> were evaluated; 88 women (58%) were treated and 64 untreated (42%) with psychotropic drugs during pregnancy. Among the 88 women treated, 23 (26%) discontinued their medication in the first trimester and the remaining 65 (74%) were exposed throughout pregnancy or in the second and third trimesters. More than two\u2010thirds (73%) of the women who remained in the study took psychotropic agents postpartum. The mean scores on the <jats:styled-content style=\"fixed-case\">SIGH<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ADS<\/jats:styled-content> were in the mild range of depressive symptoms in both the psychotropic\u2010treated and untreated groups in both pregnancy and postpartum. The majority of women had no or few symptoms of mania. Of the pregnant women treated with psychotropic agents, 66% received a guideline\u2010concordant drug, and 34% received either antidepressant monotherapy (for <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> I) or mono\u2010 or polypharmacy with a variety of other agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This sample of perinatal women with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> was characterized by mild residual symptoms of depression independent of pharmacotherapy, which poses a risk for recurrence and impaired parenting. The treatment of childbearing women with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> deserves urgent clinical and research attention to improve psychiatric outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12500","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T11:47:25Z","timestamp":1498823245000},"page":"295-304","source":"Crossref","is-referenced-by-count":20,"title":["Mood symptoms in pregnant and postpartum women with bipolar disorder: a naturalistic study"],"prefix":"10.1111","volume":"19","author":[{"given":"Kara E","family":"Driscoll","sequence":"first","affiliation":[{"name":"University of Pittsburgh  Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy K Y","family":"Sit","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eydie 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