{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:48:36Z","timestamp":1773114516332,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T00:00:00Z","timestamp":1496880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>An evidence base for the treatment of mania and bipolar depression with psychotic symptoms is lacking. Nevertheless, clinicians may have a preference for treating episodes of bipolar disorder with or without psychotic symptoms in different ways, which is likely to reflect notions of differential efficacy of treatments between these subtypes. This study aimed to investigate whether the psychopharmacological treatment of psychotic and non\u2010psychotic episodes of mania and bipolar depression, respectively, differs in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a register\u2010based study assessing the psychopharmacological treatment of all individuals receiving their first diagnosis of mania or bipolar depression between 2010 and 2012. The psychopharmacological treatment within 3\u00a0months following the time of diagnosis was considered. Potential differences in psychopharmacological treatment between the psychotic and non\u2010psychotic subtypes of mania and bipolar depression, respectively, were investigated by means of Pearson's \u03c7<jats:sup>2<\/jats:sup> test and logistic regression adjusted for sex and age at diagnosis of bipolar disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 827 patients were included in the analyses. The adjusted odds ratio (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>) for treatment with an antipsychotic was 1.71 (95% confidence interval <jats:styled-content style=\"fixed-case\">[CI]<\/jats:styled-content>: 1.18\u20102.48, <jats:italic>P<\/jats:italic>&lt;.01) for psychotic mania and 3.89 (95% CI: 1.95\u20107.76, <jats:italic>P<\/jats:italic>&lt;.001) for psychotic bipolar depression. The <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> for treatment with the combination of an antipsychotic and an anticonvulsant was 1.60 (95% CI: 1.06\u20102.43, <jats:italic>P<\/jats:italic>&lt;.05) for psychotic mania. The <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> for treatment with the combination of an antipsychotic and an antidepressant was 2.50 (95% CI: 1.43\u20104.37, <jats:italic>P<\/jats:italic>&lt;.01) for bipolar psychotic depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It would be of interest to conduct studies evaluating whether antipsychotics represent the superior pharmacological treatment for psychotic mania and psychotic bipolar depression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12504","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T05:46:39Z","timestamp":1496900799000},"page":"505-512","source":"Crossref","is-referenced-by-count":18,"title":["Psychopharmacological treatment of psychotic mania and psychotic bipolar depression compared to non\u2010psychotic mania and non\u2010psychotic bipolar depression"],"prefix":"10.1111","volume":"19","author":[{"given":"Louise B.","family":"Bj\u00f8rklund","sequence":"first","affiliation":[{"name":"Psychosis Research Unit Aarhus University Hospital  Risskov Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henriette T.","family":"Horsdal","sequence":"additional","affiliation":[{"name":"National Centre for Register\u2010based Research Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole","family":"Mors","sequence":"additional","affiliation":[{"name":"Psychosis Research Unit Aarhus University Hospital  Risskov Denmark"},{"name":"iPSYCH Lundbeck Foundation Initiative for Integrative Psychiatric Research  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Gasse","sequence":"additional","affiliation":[{"name":"National Centre for Register\u2010based Research Aarhus University  Aarhus Denmark"},{"name":"iPSYCH Lundbeck Foundation Initiative for Integrative Psychiatric Research  Aarhus Denmark"},{"name":"CIRRAU Centre for Integrated Register\u2010based Research Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8032-6208","authenticated-orcid":false,"given":"S\u00f8ren D.","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Psychosis Research Unit Aarhus University Hospital  Risskov Denmark"},{"name":"iPSYCH Lundbeck Foundation Initiative for Integrative Psychiatric Research  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-440X(03)00089-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2009.08.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.05.030"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.10.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2005.12.008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12302"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.04.024"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/15622970902823202"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622970903555881"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2013.770551"},{"key":"e_1_2_7_12_1","volume-title":"Practice guideline for the treatment of patients with bipolar disorder, second edition","author":"Hirschfeld RMA","year":"2002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2013.804195"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.07.036"},{"key":"e_1_2_7_15_1","first-page":"441","article-title":"The Danish Civil Registration System. 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