{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:41:27Z","timestamp":1783525287091,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:00:00Z","timestamp":1496361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH44801"],"award-info":[{"award-number":["MH44801"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH094398"],"award-info":[{"award-number":["MH094398"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007123","name":"Stanley Medical Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>There is an increased prevalence of obesity in schizophrenia and bipolar disorder, leading to a disproportionate risk of adverse health conditions. Prospective, long\u2010term weight gain data, however, are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed data from the Suffolk County Mental Health Project cohort of consecutive first admissions with psychosis recruited from September 1989 to December 1995 and subsequently followed for 20\u00a0years, focusing on people with schizophrenia (n=146) and bipolar disorder (n=87). The time course of weight gain was examined using a 2 (group)\u00d75 (time) mixed\u2010model repeated measures <jats:styled-content style=\"fixed-case\">ANOVA<\/jats:styled-content>, and body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) scores at the first (6\u00a0months) and second (2\u00a0years) assessments were compared to examine whether early overweight predicted later obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a statistically significant effect of time (<jats:italic>F<\/jats:italic>(1,210)=68.06, <jats:italic>P<\/jats:italic>&lt;.001) and diagnosis (<jats:italic>F<\/jats:italic>(1,210)=29.18, <jats:italic>P<\/jats:italic>&lt;.001) on <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, but not the interaction of time\u00d7diagnosis (<jats:italic>F<\/jats:italic>(1,210)=0.88, <jats:italic>P<\/jats:italic>=.48). Most participants had normal <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>s at the first two assessments. Early overweight was a predictor of eventual obesity for both groups. At the 20\u2010year follow\u2010ups, approximately 50% of the bipolar and 62% of the schizophrenia sample were obese, with a greater prevalence of obesity in schizophrenia at each assessment (all <jats:italic>P<\/jats:italic>&lt;.02), except for years 4 (<jats:italic>P<\/jats:italic>=.12) and 20 (<jats:italic>P<\/jats:italic>=.27).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nearly two\u2010thirds of the participants with schizophrenia and over half of those with bipolar disorder were obese 20\u00a0years after first hospitalization for psychosis, considerably higher than the rate for adults in New York State (27%). Early intervention may be required to prevent long\u2010term consequences of obesity\u2010related morbidity and mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12505","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T11:27:33Z","timestamp":1496402853000},"page":"336-343","source":"Crossref","is-referenced-by-count":65,"title":["Twenty\u2010year progression of body mass index in a county\u2010wide cohort of people with schizophrenia and bipolar disorder identified at their first episode of psychosis"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5514-2557","authenticated-orcid":false,"given":"Martin","family":"Strassnig","sequence":"first","affiliation":[{"name":"Department of Integrated Medical Science Charles Schmidt College of Medicine Florida Atlantic University  Boca Raton FL 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