{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:48:45Z","timestamp":1765486125409,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GQ1003B"],"award-info":[{"award-number":["01GQ1003B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["We3638\/3\u20101"],"award-info":[{"award-number":["We3638\/3\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The human brain is organized into large\u2010scale networks that dynamically interact with each other. Extensive evidence has shown characteristic changes in certain large\u2010scale networks during transitions from internally directed to externally directed attention. The aim of the present study was to compare these context\u2010dependent network interactions during emotion regulation and to examine potential alterations in remitted unipolar and bipolar disorder patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We employed a multi\u2010region generalized psychophysiological interactions analysis to quantify connectivity changes during distraction vs reappraisal pair\u2010wise across 90 regions placed throughout the four networks of interest (default\u2010mode, frontoparietal, salience, and dorsal attention networks). Using network contingency analysis and permutation testing, we estimated the likelihood that the number of significant condition\u2010dependent connectivity changes in every pair of networks exceeds the number expected by chance. We first examined the pattern of functional connectivity in 42 healthy subjects (sample I) and then compared these connectivity patterns across healthy individuals (n=23) and remitted bipolar (n=21) and unipolar disorder patients (n=21) in an independent sample <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In sample I, distraction compared to reappraisal was characterized by reduced connectivity within the default\u2010mode network and between the default\u2010mode and two cognitive control networks and increased connectivity among the cognitive control networks. In sample <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, both patient groups exhibited abnormally increased default\u2010mode intra\u2010 and inter\u2010network connectivity during distraction compared to reappraisal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study highlights the role of large\u2010scale network interactions in emotion regulation and provides preliminary evidence of default\u2010mode inter\u2010 and intra\u2010network connectivity impairments in remitted bipolar and unipolar patients during emotion regulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12512","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T15:49:28Z","timestamp":1506613768000},"page":"487-495","source":"Crossref","is-referenced-by-count":18,"title":["Large\u2010scale network functional interactions during distraction and reappraisal in remitted bipolar and unipolar patients"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5212-1646","authenticated-orcid":false,"given":"Giannis","family":"Lois","sequence":"first","affiliation":[{"name":"Department of Clinical Psychology and Neuropsychology Institute of Psychology Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin F","family":"Gerchen","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology Central Institute of Mental Health University of Heidelberg\/Medical Faculty Mannheim and Bernstein Center for Computational Neuroscience Heidelberg\/Mannheim  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kirsch","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology Central Institute of Mental Health University of Heidelberg\/Medical Faculty Mannheim and Bernstein Center for Computational Neuroscience Heidelberg\/Mannheim  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Kanske","sequence":"additional","affiliation":[{"name":"Department of Social Neuroscience Max Planck Institute for Human Cognitive and Brain Sciences  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Sch\u00f6nfelder","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology and Neuropsychology Institute of Psychology Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mich\u00e8le","family":"Wessa","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology and Neuropsychology Institute of Psychology Johannes Gutenberg\u2010University Mainz  Mainz 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