{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:09:49Z","timestamp":1791500989268,"version":"4.3.4"},"reference-count":63,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T00:00:00Z","timestamp":1499817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bipolar Disorders"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Volumetric studies on deep gray matter structures in bipolar disorder (\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      ) have reported contrasting results. Childhood trauma, a relevant environmental stressor for\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      , could account for the variability of the results, modulating differences in the amygdala and hippocampus in patients with BP compared with healthy controls (HC). Our study aimed to test this hypothesis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We assessed 105 outpatients, diagnosed with bipolar disorder type I (\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      \u2010I) or bipolar disorder type\n                      <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                      ) according to\n                      <jats:styled-content style=\"fixed-case\">DSM<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">TR<\/jats:styled-content>\n                      criteria, and 113 HC subjects. History of childhood trauma was obtained using the Childhood Trauma Questionnaire (\n                      <jats:styled-content style=\"fixed-case\">CTQ<\/jats:styled-content>\n                      ). High\u2010resolution magnetic resonance imaging was performed on all subjects and volumes of the amygdala, hippocampus, nucleus accumbens, caudate, pallidum, putamen, and thalamus were measured using FreeSurfer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      showed a global reduction of deep gray matter volumes compared to\n                      <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\n                      s. However, childhood trauma modulated the impact of the diagnosis specifically on the amygdala and hippocampus. Childhood trauma was associated with bilateral decreased volumes in\n                      <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\n                      s and increased volumes in patients with\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results suggest that childhood trauma may have a different effect in health and disease on volumes of gray matter in the amygdala and hippocampus, which are brain areas specifically involved in response to stress and emotion processing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bdi.12516","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T01:42:42Z","timestamp":1499823762000},"page":"353-362","source":"Crossref","is-referenced-by-count":74,"title":["Amygdala and hippocampus volumes are differently affected by childhood trauma in patients with bipolar disorders and healthy controls"],"prefix":"10.1111","volume":"19","author":[{"given":"Delfina","family":"Janiri","sequence":"first","affiliation":[{"name":"Psychiatry Residency Training Program Faculty of Medicine and Psychology Sapienza University of Rome  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Sani","sequence":"additional","affiliation":[{"name":"NESMOS Department (Neurosciences, Mental Health, and Sensory Organs) Sapienza University of Rome School of Medicine and Psychology Sant'Andrea Hospital  Rome Italy"},{"name":"Centro Lucio Bini  Rome Italy"},{"name":"Tufts Medical Center Tufts University School of Medicine  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro De","family":"Rossi","sequence":"additional","affiliation":[{"name":"NESMOS Department (Neurosciences, Mental Health, and Sensory Organs) Sapienza University of Rome School of Medicine and Psychology Sant'Andrea Hospital  Rome Italy"},{"name":"Centro Lucio Bini  Rome Italy"},{"name":"Department of Neurology and Psychiatry Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Piras","sequence":"additional","affiliation":[{"name":"IRCCS Santa Lucia Foundation Laboratory of Neuropsychiatry Department of Clinical and Behavioral Neurology  Rome Italy"},{"name":"Museo storico della fisica e Centro studi e ricerche Enrico Fermi  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Iorio","sequence":"additional","affiliation":[{"name":"IRCCS Santa Lucia Foundation Laboratory of Neuropsychiatry Department of Clinical and Behavioral Neurology  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerisa","family":"Banaj","sequence":"additional","affiliation":[{"name":"IRCCS Santa Lucia Foundation Laboratory of Neuropsychiatry Department of Clinical and Behavioral Neurology  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Giuseppin","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry and Psychology Fondazione Policlinico Universitario A.Gemelli Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Spinazzola","sequence":"additional","affiliation":[{"name":"Psychiatry Residency Training Program Faculty of Medicine and Psychology Sapienza University of Rome  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Maggiora","sequence":"additional","affiliation":[{"name":"Psychiatry Residency Training Program Faculty of Medicine and Psychology Sapienza University of Rome  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Ambrosi","sequence":"additional","affiliation":[{"name":"IRCCS Santa Lucia Foundation Laboratory of Neuropsychiatry Department of Clinical and Behavioral Neurology  Rome Italy"},{"name":"Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Simonetti","sequence":"additional","affiliation":[{"name":"Centro Lucio Bini  Rome Italy"},{"name":"Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7432-4249","authenticated-orcid":false,"given":"Gianfranco","family":"Spalletta","sequence":"additional","affiliation":[{"name":"IRCCS Santa Lucia Foundation Laboratory of Neuropsychiatry Department of Clinical and Behavioral Neurology  Rome Italy"},{"name":"Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.13081008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.03.036"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.06.020"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.100140"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2015.05.012"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1399-5618.2003.00087.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.56.3.254"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.186.2.121"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2012.01.035"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbr085"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.10.045"},{"key":"e_1_2_7_13_1","first-page":"68","article-title":"A review of adversity, the amygdala and the hippocampus: a consideration of developmental timing","volume":"3","author":"Tottenham N","year":"2009","journal-title":"Front Hum Neurosci"},{"key":"e_1_2_7_14_1","first-page":"943","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2000"},{"key":"e_1_2_7_15_1","volume-title":"Structured Clinical Interview for DSM\u2010IV\u2010TR Axis I Disorders, Research Version, Patient Edition. (SCID\u2010I\/P)","author":"First M","year":"2002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/87565649109540545"},{"key":"e_1_2_7_18_1","volume-title":"Structured Clinical Interview for DSM\u2010IV\u2010TR Axis I Disorders, Research Version, Non\u2010patient Edition. (SCID\u2010I\/NP)","author":"First M","year":"2002"},{"key":"e_1_2_7_19_1","volume-title":"Structured Clinical Interview for DSM\u2010IV Axis II Personality Disorders, (SCID\u2010II)","author":"First M","year":"1997"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2134(02)00541-0"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.151.8.1132"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013058625719"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2007.01079.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2009.04.012"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.20532"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00569-X"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.016"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.02.010"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.12.033"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.06.018"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.03.037"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.227"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2011.565"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7687.2009.00852.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2005.05.014"},{"issue":"6","key":"e_1_2_7_39_1","first-page":"339","article-title":"Impression of the 1975 general meeting of the japan nursing association. Disappointing attitude of the assembly toward the nursing system","volume":"31","author":"Takano E","year":"1975","journal-title":"Hokenfu Zasshi"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.12.1115"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4927(03)00023-4"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2015.07.016"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2008.01246.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(96)00162-X"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.12.2072"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.112.111047"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2005.06.004"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1521\/jscp.2007.26.4.460"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2008.00656.x"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.12.039"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2014.03.046"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01328-2"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.10.013"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-13-4"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2011.01756.x"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.12.055"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2014.12.008"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12394"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.700"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986709787909604"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199901000-00008"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00561.x"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0857"},{"key":"e_1_2_7_64_1","first-page":"79","article-title":"How to control confounding effects by statistical analysis","volume":"5","author":"Pourhoseingholi MA","year":"2012","journal-title":"Gastroenterol Hepatol Bed Bench"}],"container-title":["Bipolar Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbdi.12516","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bdi.12516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:06:02Z","timestamp":1695546362000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bdi.12516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,12]]},"references-count":63,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/bdi.12516"],"URL":"https:\/\/doi.org\/10.1111\/bdi.12516","archive":["Portico"],"relation":{},"ISSN":["1398-5647","1399-5618"],"issn-type":[{"value":"1398-5647","type":"print"},{"value":"1399-5618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,12]]}}}