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However, few studies to date have compared these two mood disorders directly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Matched groups of 26 <jats:styled-content style=\"fixed-case\">BDD<\/jats:styled-content> type I patients, 26 <jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content> patients and 26 healthy controls underwent functional magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content>) while performing the n\u2010back working memory task. A whole\u2010brain <jats:styled-content style=\"fixed-case\">ANOVA<\/jats:styled-content> was used to compare the three groups and clusters of significant difference were examined further using region\u2010of\u2010interest (<jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The whole\u2010brain <jats:styled-content style=\"fixed-case\">ANOVA<\/jats:styled-content> revealed a single cluster of significant difference in the medial frontal cortex. The <jats:styled-content style=\"fixed-case\">BDD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content> patients both showed failure to deactivate in this area compared to the controls. The <jats:styled-content style=\"fixed-case\">BDD<\/jats:styled-content> patients showed significantly greater failure of deactivation than the <jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content> patients, which was not accounted for by differences in severity or chronicity of illness between them.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Failure of deactivation, considered to reflect default mode network dysfunction, is present to a greater extent in bipolar than unipolar depression. The study of this network may be useful in the search for brain markers that distinguish the two disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bdi.12517","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T10:52:41Z","timestamp":1500288761000},"page":"386-395","source":"Crossref","is-referenced-by-count":49,"title":["Differential failure to deactivate the default mode network in unipolar and bipolar depression"],"prefix":"10.1111","volume":"19","author":[{"given":"Elena","family":"Rodr\u00edguez\u2010Cano","sequence":"first","affiliation":[{"name":"FIDMAG Germanes Hospital\u00e0ries Research Foundation  Barcelona Spain"},{"name":"Benito Menni Complex Assistencial en Salut Mental  Sant Boi Spain"},{"name":"Escola de Doctorat Universitat de Barcelona  Barcelona 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